For research use only. Not for therapeutic Use.
G1023(CAT: I027868) is a potent and selective antagonist of the transient receptor potential vanilloid 1 (TRPV1) channel, widely studied in pain and inflammation research. By inhibiting TRPV1, it blocks the channel’s activation by heat, acidity, and endogenous ligands, making it valuable for exploring mechanisms underlying chronic pain, neuropathy, and inflammatory diseases. G1023 is commonly used in preclinical studies to investigate TRPV1-mediated nociceptive pathways and to evaluate its therapeutic potential in pain management. Its specificity and efficacy make it an essential tool for advancing our understanding of sensory physiology and developing novel analgesics.
| Catalog Number | I027868 |
| Synonyms | G1023; G-1023; G 1023 |
| Molecular Formula | C18H19F4N5O3 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | [4-(4-Methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-2-fluoro-5-methoxy-phenyl]-morpholin-4-yl-methanone |
| InChI | InChI=1S/C18H19F4N5O3/c1-23-15-11(18(20,21)22)9-24-17(26-15)25-13-8-12(19)10(7-14(13)29-2)16(28)27-3-5-30-6-4-27/h7-9H,3-6H2,1-2H3,(H2,23,24,25,26) |
| InChIKey | XRGIIJXYVHEZPX-UHFFFAOYSA-N |
| SMILES | O=C(C1=CC(OC)=C(NC2=NC=C(C(F)(F)F)C(NC)=N2)C=C1F)N3CCOCC3 |
