For research use only. Not for therapeutic Use.
G150 is a highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with an IC50 of 10.2 nM. G150 represses dsDNA-triggered interferon expression, and G150 can be used for the research of inflammatory[1].
G150 (0.1-100 μM; 1 h) affects IFNB1 and CXCL10 expression in human THP1 cells and primary human macrophages[1].
G150 (5-10 μM; 1 h) affects dsDNA sensing in THP1 cells and primary human macrophages[1].
G150 (0.1-100 μM; 1 h) affects the NF-κB pathway activation in THP1-Dual cells[1].
| Catalog Number | I018986 |
| CAS Number | 2369751-30-2 |
| Synonyms | 1-[9-(6-aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-hydroxyethanone |
| Molecular Formula | C18H16Cl2N4O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C18H16Cl2N4O2/c19-12-5-10(9-1-2-14(21)22-6-9)16-11-7-24(15(26)8-25)4-3-13(11)23-18(16)17(12)20/h1-2,5-6,23,25H,3-4,7-8H2,(H2,21,22) |
| InChIKey | VVUOUIPXYFIWLE-UHFFFAOYSA-N |
| SMILES | C1CN(CC2=C1NC3=C2C(=CC(=C3Cl)Cl)C4=CN=C(C=C4)N)C(=O)CO |
| Reference | [1]. Lama L, et al. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun. 2019 May 21;10(1):2261. |
