G9a-IN-1

• CAT Number: I020984
• CAS Number: 1350752-07-6
• Molecular Formula: C24H36ClN5O2
• Molecular Weight: 462.03
• Purity: ≥95%
• Synonyms: 2-chloro-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine
• InChI: InChI=1S/C24H36ClN5O2/c1-17(2)30-12-7-18(8-13-30)26-23-19-15-21(31-3)22(16-20(19)27-24(25)28-23)32-14-6-11-29-9-4-5-10-29/h15-18H,4-14H2,1-3H3,(H,26,27,28)
• InChIKey: GHTIAKXLWWMKSI-UHFFFAOYSA-N
• SMILES: CC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OCCCN4CCCC4)Cl

G9a-IN-1（Cat No.:I020984）is a small molecule inhibitor that targets G9a, a histone methyltransferase involved in the regulation of gene expression through the methylation of histone H3 at lysine 9 (H3K9). By inhibiting G9a, G9a-IN-1 disrupts epigenetic silencing mechanisms, potentially reactivating genes that are suppressed in diseases like cancer and neurodegenerative disorders. It is being studied for its ability to modulate gene expression and affect cellular processes such as differentiation, proliferation, and apoptosis. Ongoing research is focused on evaluating its therapeutic potential in cancer therapy and other conditions related to epigenetic regulation.