Gabapentin

• CAT Number: I004258
• CAS Number: 60142-96-3
• Molecular Formula: C9H17NO2
• Molecular Weight: 171.2
• Purity: ≥95%
• Synonyms: 2-[1-(aminomethyl)cyclohexyl]acetic acid
• Target: GABA Receptor
• Solubility: H2O: 34 mg/mL, DMSO: ＜1 mg/mL
• Storage: 3 years -20C powder
• IC50: 140 nM (α2δ subunit of calcium channel) [1]
• InChI: InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)
• InChIKey: UGJMXCAKCUNAIE-UHFFFAOYSA-N

Gabapentin (CAT: I004258) is a medication used primarily to treat epilepsy and neuropathic pain. It belongs to the class of anticonvulsant drugs and works by affecting the chemicals and nerves in the body that are involved in seizures and pain signals. Gabapentin is thought to modulate the activity of certain neurotransmitters, such as gamma-aminobutyric acid (GABA), in the brain, which helps to reduce abnormal electrical activity and alleviate pain. In addition to its approved uses, gabapentin may also be prescribed off-label for other conditions, including anxiety disorders and restless legs syndrome.

Reference

1:Visceral Hyperalgesia: When to Consider Gabapentin Use in Neonates-Case Study and Review. Asaro J, Robinson CA, Levy PT.Child Neurol Open. 2017 Feb 10;4:2329048X17693123. doi: 10.1177/2329048X17693123. eCollection 2017 Jan-Dec. PMID: 28503628 Free PMC Article
2:Law enforcement-derived data on gabapentin diversion and misuse, 2002-2015: diversion rates and qualitative research findings. Buttram ME, Kurtz SP, Dart RC, Margolin ZR.Pharmacoepidemiol Drug Saf. 2017 May 10. doi: 10.1002/pds.4230. [Epub ahead of print] PMID: 28493425
3:Risk to heroin users of polydrug use of pregabalin or gabapentin. Lyndon A, Audrey S, Wells C, Burnell ES, Ingle S, Hill R, Hickman M, Henderson G.Addiction. 2017 May 10. doi: 10.1111/add.13843. [Epub ahead of print] PMID: 28493329
4:Combination therapy of levetiracetam and gabapentin against nonconvulsive seizures induced by penetrating traumatic brain injury. Lu XM, Cao Y, Mountney A, Liao Z, Shear DA, Tortella FC.J Trauma Acute Care Surg. 2017 Apr 27. doi: 10.1097/TA.0000000000001470. [Epub ahead of print] PMID: 28452872
5:Prevalence of Gabapentin Abuse: Comparison with Agents with Known Abuse Potential in a Commercially Insured US Population. Peckham AM, Fairman KA, Sclar DA.Clin Drug Investig. 2017 Apr 27. doi: 10.1007/s40261-017-0530-3. [Epub ahead of print] PMID: 28451875
6:Impact of gabapentin on neuronal high voltage-activated Ca2+ channel properties of injured-side axotomized and adjacent uninjured dorsal root ganglions in a rat model of spinal nerve ligation. Zhu M, Sun X, Chen X, Xiao H, Duan M, Xu J.Exp Ther Med. 2017 Mar;13(3):851-860. doi: 10.3892/etm.2017.4071. Epub 2017 Jan 20. PMID: 28450909 Free PMC Article
7:Use of gabapentin in the treatment of chronic pain in an adolescent with sickle cell disease. Correia CR, Soares AT, Azurara L, Palaré MJ.BMJ Case Rep. 2017 Apr 21;2017. pii: bcr-2016-218614. doi: 10.1136/bcr-2016-218614. PMID: 28432164
8:Gabapentin Attenuates Ocular Inflammation: In vitro and In vivo Studies. Anfuso CD, Olivieri M, Fidilio A, Lupo G, Rusciano D, Pezzino S, Gagliano C, Drago F, Bucolo C.Front Pharmacol. 2017 Apr 4;8:173. doi: 10.3389/fphar.2017.00173. eCollection 2017. PMID: 28420991 Free PMC Article
9:Stability of gabapentin in extemporaneously compounded oral suspensions. Friciu M, Roullin VG, Leclair G.PLoS One. 2017 Apr 17;12(4):e0175208. doi: 10.1371/journal.pone.0175208. eCollection 2017. PMID: 28414771 Free PMC Article
10:The comparative preemptive analgesic efficacy of addition of vitamin B complex to gabapentin versus gabapentin alone in women undergoing cesarean section under spinal anesthesia: A prospective randomized double-blind study. Khezri MB, Nasseh N, Soltanian G.Medicine (Baltimore). 2017 Apr;96(15):e6545. doi: 10.1097/MD.0000000000006545. PMID: 28403084 Free PMC Article