For research use only. Not for therapeutic Use.
Gacyclidine（Cat No.:I006927）is a potent, non-competitive NMDA receptor antagonist that has been explored for its potential use in treating neurological disorders, particularly those involving excitotoxicity such as ischemic stroke and Alzheimer’s disease. By inhibiting the NMDA receptor, gacyclidine reduces excessive glutamate activity, which can lead to neuronal damage. In preclinical studies, it has shown neuroprotective effects and the ability to improve cognitive function in animal models. Although promising, gacyclidine’s clinical development has been limited, and further research is needed to evaluate its safety, efficacy, and therapeutic potential in humans.
| Catalog Number | I006927 |
| CAS Number | 68134-81-6 |
| Synonyms | Gacyclidine; OTO-311; GK-11; OTO 311; GK 11; OTO311; GK11;1-((1S,2S)-2-methyl-1-(thiophen-2-yl)cyclohexyl)piperidine |
| Molecular Formula | C16H25NS |
| Purity | ≥95% |
| Target | N-methyl-D-aspartate Receptor Antagonist |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| IUPAC Name | 1-[(1R,2S)-2-methyl-1-thiophen-2-ylcyclohexyl]piperidine |
| InChI | InChI=1S/C16H25NS/c1-14-8-3-4-10-16(14,15-9-7-13-18-15)17-11-5-2-6-12-17/h7,9,13-14H,2-6,8,10-12H2,1H3/t14-,16+/m0/s1 |
| InChIKey | DKFAAPPUYWQKKF-GOEBONIOSA-N |
| SMILES | C[C@H]1CCCC[C@@]1(C2=CC=CS2)N3CCCCC3 |
