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72573-82-1-Gadoteric Acid Gadoteric Acid

Gadoteric Acid

For research use only. Not for therapeutic Use.

  • CAT Number: M009883
  • CAS Number: 72573-82-1
  • Molecular Formula: C16H25GdN4O8
  • Molecular Weight: 558.65
  • Purity: ≥95%
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Related Small Molecules: Lithium hydrogen-6-methylpyridine-2-boronate     4-METHYLHEXANOIC ACID     3-(1-Pyrrolidinoethyl)phenylboronic acid    

Gadoteric acid (gadoterate meglumine, trade names Artirem, Dotarem) is a macrocycle-structured gadolinium-based MRI contrast agent (GBCA). It consists of the organic acid DOTA as a chelating agent, and gadolinium (Gd3+), and is used in form of the meglumine salt (Gadoterate meglumine).


CAS Number 72573-82-1
Synonyms

Gadoteric acid;Gadoteric;Gadolinium 2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetic acid;Gadolinate(1-),[1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetato(4-)-kN1,kN4,kN7,kN10,kO1,kO4,kO7,kO10]-, hydrogen (1:1)

Molecular Formula C16H25GdN4O8
Purity ≥95%
Storage Store at RT
InChI 1S/C16H28N4O8.Gd/c21-13(22)9-17-1-2-18(10-14(23)24)5-6-20(12-16(27)28)8-7-19(4-3-17)11-15(25)26;/h1-12H2,(H,21,22)(H,23,24)(H,25,26)(H,27,28);/q;+3/p-3
InChIKey GFSTXYOTEVLASN-UHFFFAOYSA-K
SMILES C1CN(CCN(CCN(CCN1CC(=O)O)CC(=O)[O-])CC(=O)[O-])CC(=O)[O-].[Gd+3]
Reference

1: Gheuens E, Daelemans R, Mesens S. Dialysability of gadoteric acid in patients
with end-stage renal disease undergoing hemodialysis. Invest Radiol. 2014
Aug;49(8):505-8. doi: 10.1097/RLI.0000000000000045. PubMed PMID: 24619209.
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2: Renz DM, Durmus T, B&#246;ttcher J, Taupitz M, Diekmann F, Huppertz A, Pfeil A,
Maurer MH, Streitparth F, Bick U, Hamm B, Fallenberg EM. Comparison of gadoteric
acid and gadobutrol for detection as well as morphologic and dynamic
characterization of lesions on breast dynamic contrast-enhanced magnetic
resonance imaging. Invest Radiol. 2014 Jul;49(7):474-84. doi:
10.1097/RLI.0000000000000039. PubMed PMID: 24637587.

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3: Balassy C, Roberts D, Miller SF. Safety and efficacy of gadoteric acid in
pediatric magnetic resonance imaging: overview of clinical trials and
post-marketing studies. Pediatr Radiol. 2015 Nov;45(12):1831-41. doi:
10.1007/s00247-015-3394-9. Epub 2015 Jun 5. Review. PubMed PMID: 26045036.

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4: Budjan J, Ong M, Riffel P, Morelli JN, Michaely HJ, Schoenberg SO, Haneder S.
CAIPIRINHA-Dixon-TWIST (CDT)-volume-interpolated breath-hold examination (VIBE)
for dynamic liver imaging: comparison of gadoterate meglumine, gadobutrol and
gadoxetic acid. Eur J Radiol. 2014 Nov;83(11):2007-12. doi:
10.1016/j.ejrad.2014.08.003. Epub 2014 Aug 17. PubMed PMID: 25172427.

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5: Maurer M, Heine O, Wolf M, Durmus T, Wagner M, Hamm B. Tolerability and
diagnostic value of gadoteric acid in the general population and in patients with
risk factors: results in more than 84,000 patients. Eur J Radiol. 2012
May;81(5):885-90. doi: 10.1016/j.ejrad.2011.04.022. Epub 2011 May 8. PubMed PMID:
21555197.

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6: Seithe T, Braun J, Wolf M, Vahldiek J, Wolny D, Auer J, Pociej J, Heine O,
Hamm B, de Bucourt M. Diagnostic efficacy and safety of gadoteric acid MR
mammography in 1537 patients. Eur J Radiol. 2016 Dec;85(12):2281-2287. doi:
10.1016/j.ejrad.2016.10.013. Epub 2016 Oct 14. PubMed PMID: 27842678.
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7: Apodaca-Torrez FR, Goldenberg A, Lobo EJ, Farah JF, Trivi&#241;o T, Montero EF,
Schraibman V, Benvenuto RB, Artigiani Neto R. Evaluation of the effects of
noniodinized and iodinized ionic contrast media and gadoteric acid in acute
necrotizing pancreatitis: experimental study in rabbits. Pancreas. 2007
Nov;35(4):e41-4. PubMed PMID: 18090230.

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