Galanthaminone

• CAT Number: I003829
• CAS Number: 510-77-0
• Molecular Formula: C17H19NO3
• Molecular Weight: 285.34
• Purity: ≥95%
• Target: Cholinesterase (ChE)
• Solubility: 10 mM in DMSO
• Storage: 2-8°C
• IUPAC Name: (1S,12S)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-one
• InChI: InChI=1S/C17H19NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,14H,7-10H2,1-2H3/t14-,17-/m0/s1
• InChIKey: QENVUHCAYXAROT-YOEHRIQHSA-N
• SMILES: CN1CCC23C=CC(=O)CC2OC4=C(C=CC(=C34)C1)OC

Galanthaminone (Cat No.: I003829) is a competitive and reversible inhibitor of acetylcholinesterase (AChE), an enzyme responsible for breaking down acetylcholine in the brain. By inhibiting AChE, Galanthaminone increases acetylcholine levels, which can enhance cognitive function. This property makes it valuable in the treatment of various memory impairment diseases, including Alzheimer’s disease. If you need to, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

[1]. Woodruff-Pak DS, et al. Galantamine: effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):2089-94.

[2]. Greenblatt HM, et al. Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution. FEBS Lett. 1999 Dec 17;463(3):321-6.

[3]. Heinrich M, et al. Galanthamine from snowdrop–the development of a modern drug against Alzheimer/’s disease from local Caucasian knowledge. J Ethnopharmacol. 2004 Jun;92(2-3):147-62.