Galidesivir HCl

For research use only. Not for therapeutic Use.

  • CAT Number: I006930
  • CAS Number: 222631-44-9 (HCl)
  • Molecular Formula: C11H16ClN5O3
  • Molecular Weight: 301.731
  • Purity: ≥95%
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Galidesivir, also known as BCX4430 and Immucillin-A, is an antiviral drug and an adenosine analog. Galidesivir was originally intended as a treatment for Hepatitis C, but subsequently developed as a potential treatment for deadly filovirus infections such as Ebola virus disease and Marburg virus disease. Galidesivir also shows broad-spectrum antiviral effectiveness against a range of other RNA virus families, including bunyaviruses, arenaviruses, paramyxoviruses, coronaviruses and flaviviruses. BCX4430 has been demonstrated to protect against both Ebola and Marburg viruses in both rodents and monkeys, even when administered up to 48 hours after infection.


Catalog Number I006930
CAS Number 222631-44-9 (HCl)
Synonyms

Galidesivir; BCX4430; BCX 4430; BCX-4430. Immucillin-A.;(2S,3S,4R,5R)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol hydrochloride

Molecular Formula C11H16ClN5O3
Purity ≥95%
Solubility Soluble in DMSO
Storage 0 - 4°C for short term or -20 °C for long term
Reference

</br>1:Effects of Clove Oil and Lidocaine-HCl Anesthesia on Water Parameter during Simulated Transportation in the Marine Medaka, <i>Oryzias dancena</i>. Park IS, Gil HW, Lee TH, Nam YK, Lim SG, Kim DS.Dev Reprod. 2017 Mar;21(1):19-33. doi: 10.12717/DR.2017.21.1.019. Epub 2017 Mar 31. PMID: 28484741 Free PMC Article</br>2:Olive (Olea europaea) leaf methanolic extract prevents HCl/ethanol-induced gastritis in rats by attenuating inflammation and augmenting antioxidant enzyme activities. Al-Quraishy S, Othman MS, Dkhil MA, Abdel Moneim AE.Biomed Pharmacother. 2017 Apr 29;91:338-349. doi: 10.1016/j.biopha.2017.04.069. [Epub ahead of print] PMID: 28463797 </br>3:HCl dissociating on a rigid Au(111) surface: A six-dimensional quantum mechanical study on a new potential energy surface based on the RPBE functional. Liu T, Fu B, Zhang DH.J Chem Phys. 2017 Apr 28;146(16):164706. doi: 10.1063/1.4982051. PMID: 28456190 </br>4:A new ab initio potential energy surface of LiClH (1A/’) system and quantum dynamics calculation for Li + HCl (v = 0, j = 0-2) → LiCl + H reaction. Tan RS, Zhai HC, Yan W, Gao F, Lin SY.J Chem Phys. 2017 Apr 28;146(16):164305. doi: 10.1063/1.4982066. PMID: 28456188 </br>5:Spectroscopic Characterization of the Reaction Products between the Criegee Intermediate CH<sub>2</sub> OO and HCl. Cabezas C, Endo Y.Chemphyschem. 2017 Apr 27. doi: 10.1002/cphc.201700446. [Epub ahead of print] PMID: 28449411 </br>6:Formulation, release characteristics, and bioavailability study of gastroretentive floating matrix tablet and floating raft system of Mebeverine HCl. El Nabarawi MA, Teaima MH, Abd El-Monem RA, El Nabarawy NA, Gaber DA.Drug Des Devel Ther. 2017 Apr 3;11:1081-1093. doi: 10.2147/DDDT.S131936. eCollection 2017. PMID: 28435220 Free PMC Article</br>7:Lipids bearing extruded-spheronized pellets for extended release of poorly soluble antiemetic agent-Meclizine HCl. Qazi F, Shoaib MH, Yousuf RI, Nasiri MI, Ahmed K, Ahmad M.Lipids Health Dis. 2017 Apr 12;16(1):75. doi: 10.1186/s12944-017-0466-x. PMID: 28403892 Free PMC Article</br>8:Acute exposure of primary rat soleus muscle to zilpaterol HCl (β2 adrenergic agonist), TNFα, or IL-6 in culture increases glucose oxidation rates independent of the impact on insulin signaling or glucose uptake. Cadaret CN, Beede KA, Riley HE, Yates DT.Cytokine. 2017 Apr 5;96:107-113. doi: 10.1016/j.cyto.2017.03.014. [Epub ahead of print] PMID: 28390265 </br>9:Effects of anabolic implants and ractopamine-HCl on muscle fiber morphometrics, collagen solubility, and tenderness of beef longissimus lumborum steaks. Ebarb SM, Phelps KJ, Drouillard JS, Maddock-Carlin KR, Vaughn MA, Burnett DD, Noel JA, Van Bibber-Krueger CL, Paulk CB, Grieger DM, Gonzalez JM.J Anim Sci. 2017 Mar;95(3):1219-1231. doi: 10.2527/jas.2016.1263. PMID: 28380530 </br>10:Comparative plasma and tissue distribution of Sun Pharma/’s generic doxorubicin HCl liposome injection versus Caelyx<sup>®</sup> (doxorubicin HCl liposome injection) in syngeneic fibrosarcoma-bearing BALB/c mice and Sprague-Dawley rats. Burade V, Bhowmick S, Maiti K, Zalawadia R, Jain D, Rajamannar T.Cancer Chemother Pharmacol. 2017 May;79(5):899-913. doi: 10.1007/s00280-017-3278-9. Epub 2017 Mar 27. PMID: 28349166 Free PMC Article

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