For research use only. Not for therapeutic Use.
Gallocyanine chloride, a synthetic blue dyestuff, blocks DKK1 inhibitory activity by disrupting DKK1/LRP6 interaction. Its association with LRP6 is weak (IC50 of about 3 μM in the inhibition of DKK1 binding). Gallocyanine dye acts as a potential agent for the research of Alzheimer’s disease and related neurodegenerative tauopathies[1].
| Catalog Number | M050708 |
| CAS Number | 1562-85-2 |
| Synonyms | 7-(dimethylamino)-4-hydroxy-3-oxophenoxazin-10-ium-1-carboxylic acid;chloride |
| Molecular Formula | C15H13ClN2O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C15H12N2O5.ClH/c1-17(2)7-3-4-9-11(5-7)22-14-12(16-9)8(15(20)21)6-10(18)13(14)19;/h3-6,19H,1-2H3,(H,20,21);1H |
| InChIKey | AQSOTOUQTVJNMY-UHFFFAOYSA-N |
| SMILES | CN(C)C1=CC2=C(C=C1)[NH+]=C3C(=CC(=O)C(=C3O2)O)C(=O)O.[Cl-] |
| Reference | [1]. Spyros Mpousis, et al. Synthesis and evaluation of gallocyanine dyes as potential agents for the treatment of Alzheimer’s disease and related neurodegenerative tauopathies. Eur J Med Chem. 2016 Jan 27;108:28-38. |
