Gambogic Acid

• CAT Number: I002945
• CAS Number: 2752-65-0
• Molecular Formula: C38H44O8
• Molecular Weight: 628.80
• Purity: ≥95%
• Synonyms: (Z)-4-((1S,3aR,5S,11R,14aS)-8-hydroxy-2,2,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpent-3-en-1-yl)-4,7-dioxo-2,3a,4,5,7,11-hexahydro-1H-1,5-methanofuro[3,2-g]pyrano[3,2-b]xanthen-3a-yl)-2-methylbut-2-enoic acid
• Target: Autophagy
• Solubility: DMSO 25 mg/ml; water <1 mg/ml
• Storage: store at -20℃
• IC50: 1.21 uM (Bcl-2); 1.47 uM (Bcl-xl)
• IUPAC Name: (Z)-4-[(1S,2S,8R,17S,19R)-12-hydroxy-8,21,21-trimethyl-5-(3-methylbut-2-enyl)-8-(4-methylpent-3-enyl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.02,15.02,19.04,13.06,11]docosa-4(13),5,9,11,15-pentaen-19-yl]-2-methylbut-2-enoic acid
• InChI: InChI=1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-/t23-,27+,36-,37+,38-
• InChIKey: GEZHEQNLKAOMCA-RRZNCOCZSA-N
• SMILES: C/C(C(O)=O)=C/C[C@@]1(OC(C)(C)[C@]2([H])C3)[C@@]2(OC4=C(C5=C6C=C[C@](CC/C=C(C)/C)(C)O5)C/C=C(C)/C)C(C(C4=C6O)=O)=C[C@@]3([H])C1=O

Gambogic acid (CAT: I002945) has been found to exert its anticancer effects through the modulation of B-cell lymphoma 2 (BCL-2) family proteins. BCL-2 family proteins play a critical role in regulating apoptosis (programmed cell death). Gambogic acid has been shown to induce apoptosis in cancer cells by inhibiting anti-apoptotic proteins such as BCL-2 and BCL-XL while promoting the expression of pro-apoptotic proteins like BAX and BAK. This imbalance in the expression of BCL-2 family proteins leads to mitochondrial dysfunction and activation of caspases, ultimately triggering apoptosis in cancer cells. The ability of gambogic acid to target BCL-2 family proteins makes it a promising candidate for the development of novel anticancer therapies.