Gamma-Mangostin

• CAT Number: R008040
• CAS Number: 31271-07-5
• Molecular Formula: C23H24O6
• Molecular Weight: 396.43
• Purity: ≥95%
• Synonyms: 1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one
• InChI: InChI=1S/C23H24O6/c1-11(2)5-7-13-15(24)9-18-20(22(13)27)23(28)19-14(8-6-12(3)4)21(26)16(25)10-17(19)29-18/h5-6,9-10,24-27H,7-8H2,1-4H3
• InChIKey: VEZXFTKZUMARDU-UHFFFAOYSA-N
• SMILES: CC(=CCC1=C(C2=C(C=C1O)OC3=C(C2=O)C(=C(C(=C3)O)O)CC=C(C)C)O)C

Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer[2]. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes[1][2][3][4][5].
Gamma-Mangostin (0.5, 2.5, 5 μM; 2 hours) as an insulin sensitizer, alleviates hyperglycemia and is nontoxic to both vascular smoothing cells isolated from the external carotid artery in SD rats and FL83B mouse hepatocytes[5].
Gamma-Mangostin (0.5, 1, 2 mg/kg; Oral gavage (p.o.); 14 days) significantly reduces fasting blood glucose, cholesterol, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), and ameliorates damaged hepatocytes, primarily swelling, hydropic changes, and necrotic cells in the streptozotocin (STZ) (HY-13753) (30 mg/kg) induced diabetic BALB/C mouse model[3].
Gamma-Mangostin (1, 2, 4 mg/kg; Oral gavage (p.o.); 14 days) significantly reduces blood urea nitrogen (BUN) and creatinine in plasma, and ameliorates the damage to renal proximal tubular cells in BALB/C mice with streptozotocin (STZ) (HY-13753) (30 mg/kg) induced diabetes[4].
Gamma-Mangostin (0.1, 0.2, 0.4 mg; Oral gavage (p.o.); 4 weeks) can reduce fasting blood glucose levels and oral glucose tolerance tests in diabetic ICR mice[5].

Reference

[1]. Chairungsrilerd N, et al. Gamma-mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):25-31.
 [Content Brief]

[2]. Yokoyama T, et al. Discovery of γ-Mangostin as an Amyloidogenesis Inhibitor. Sci Rep. 2015 Aug 27;5:13570.
 [Content Brief]

[3]. Husen S A, et al. Hepatoprotective Effect of Gamma-mangostin for Amelioration of Impaired Liver Structure and Function in Streptozotocin-induced Diabetic Mice. 2018 IOP Conf. Ser.: Earth Environ. Sci. 217 012031

[4]. Husen S A, et al. Renal protective effects of gamma-mangostin in streptozotocin-induced diabetic mice[J]. Indian Journal of Forensic Medicine & Toxicology, 2020, 14(3): 1251-1256.

[5]. Chen, S P, Lue, et al.Gamma-mangostin of Garcinia mangostana peels ameliorates hyperglycemia in synergism of insulin. The FASEB Journal, 33: 694.11-694.11.