For research use only. Not for therapeutic Use.
Ganciclovir Sodium（Cat No.:M001234）is an antiviral agent primarily used in the treatment and prevention of cytomegalovirus (CMV) infections, particularly in immunocompromised patients such as those undergoing organ transplantation or with HIV/AIDS. It functions by inhibiting viral DNA synthesis through selective phosphorylation by viral thymidine kinase. This inhibition leads to the suppression of viral replication. Ganciclovir sodium is administered intravenously or as an oral prodrug, Valganciclovir, for more convenient administration. Its primary indications include CMV retinitis and CMV prevention in transplant recipients. Side effects include myelosuppression and renal toxicity.
| Catalog Number | M001234 |
| CAS Number | 107910-75-8 |
| Molecular Formula | C9H12N5NaO4 |
| Purity | ≥95% |
| Target | Cell Cycle/DNA Damage |
| Storage | Store at -20°C |
| IUPAC Name | sodium;2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)purin-6-olate |
| InChI | InChI=1S/C9H13N5O4.Na/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16;/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17);/q;+1/p-1 |
| InChIKey | JJICLMJFIKGAAU-UHFFFAOYSA-M |
| SMILES | C1=NC2=C(N1COC(CO)CO)N=C(N=C2[O-])N.[Na+] |
| Reference | </br>1:Stability of ganciclovir sodium in an infusion-pump syringe. Mulye NV, Turco SJ, Speaker TJ.Am J Hosp Pharm. 1994 May 15;51(10):1348-9. No abstract available. PMID: 8085576 </br>2:Stability of ganciclovir sodium and amino acids in parenteral nutrient solutions. Johnson CE, Jacobson PA, Chan E.Am J Hosp Pharm. 1994 Feb 15;51(4):503-8. PMID: 8017417 </br>3:[Stability of dilute solutions of ganciclovir sodium (Cymevan) in polypropylene syringes and PVC perfusion bags]. Phaypradith S, Vigneron J, Perrin A, Durney-Archeray MJ, Hoffman MA, Hoffman M.J Pharm Belg. 1992 Nov-Dec;47(6):494-8. French. PMID: 1289490 </br>4:Stability of ganciclovir sodium in 5% dextrose injection and in 0.9% sodium chloride injection over 35 days. Parasrampuria J, Li LC, Stelmach AH, Sykes TR, Gordon GA.Am J Hosp Pharm. 1992 Jan;49(1):116-8. PMID: 1570851 </br>5:Stability and compatibility of ganciclovir sodium in 5% dextrose injection over 35 days. Silvestri AP, Mitrano FP, Baptista RJ, Williams DA.Am J Hosp Pharm. 1991 Dec;48(12):2641-3. PMID: 1814209 </br>6:Visual compatibility of ganciclovir sodium and total parenteral nutrient solution during simulated Y-site injection. Outman WR, Mitrano FP, Baptista RJ.Am J Hosp Pharm. 1991 Jul;48(7):1538-9. No abstract available. PMID: 1909095 </br>7:Stability of ganciclovir sodium (DHPG sodium) in 5% dextrose or 0.9% sodium chloride injections. Visor GC, Lin LH, Jackson SE, Winterle JS, Lee G, Kenley RA.Am J Hosp Pharm. 1986 Nov;43(11):2810-2. PMID: 3492139 |
