Ganirelix acetate

For research use only, not for therapeutic use.

  • CAT Number: M114172
  • CAS Number: 129311-55-3
  • Molecular Formula: C84H121ClN18O17
  • Molecular Weight: 1690.451
  • Purity: ≥95%
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Ganirelix acetate(CAT: M114172) is a gonadotropin-releasing hormone receptor (GNRHR) antagonist. Formulations containing ganirelix have been used to prevent premature ovulation in women undergoing in vitro fertilization. This product is used for medical research and development and other scientific research purposes.


Catalog Number M114172
CAS Number 129311-55-3
Molecular Formula C84H121ClN18O17
Purity ≥95%
Storage -20°C
IUPAC Name (2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-6-[bis(ethylamino)methylideneamino]hexanoyl]amino]-4-methylpentanoyl]amino]-6-[bis(ethylamino)methylideneamino]hexanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide;acetic acid
InChI InChI=1S/C80H113ClN18O13.2C2H4O2/c1-9-84-79(85-10-2)88-38-17-15-24-60(70(104)94-62(41-49(5)6)71(105)93-61(25-16-18-39-89-80(86-11-3)87-12-4)78(112)99-40-20-26-68(99)77(111)90-50(7)69(82)103)92-73(107)64(44-53-30-35-59(102)36-31-53)97-76(110)67(48-100)98-75(109)66(46-55-21-19-37-83-47-55)96-74(108)65(43-52-28-33-58(81)34-29-52)95-72(106)63(91-51(8)101)45-54-27-32-56-22-13-14-23-57(56)42-54;2*1-2(3)4/h13-14,19,21-23,27-37,42,47,49-50,60-68,100,102H,9-12,15-18,20,24-26,38-41,43-46,48H2,1-8H3,(H2,82,103)(H,90,111)(H,91,101)(H,92,107)(H,93,105)(H,94,104)(H,95,106)(H,96,108)(H,97,110)(H,98,109)(H2,84,85,88)(H2,86,87,89);2*1H3,(H,3,4)/t50-,60-,61+,62+,63-,64+,65-,66-,67+,68+;;/m1../s1
InChIKey OVBICQMTCPFEBS-SATRDZAXSA-N
SMILES CCNC(=NCCCCC(C(=O)NC(CC(C)C)C(=O)NC(CCCCN=C(NCC)NCC)C(=O)N1CCCC1C(=O)NC(C)C(=O)N)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CN=CC=C3)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)C(CC5=CC6=CC=CC=C6C=C5)NC(=O)C)NCC.CC(=O)O.CC(=O)O
Reference

1.<span style=”font-family: Arial, sans-serif; font-size: 13px;”>Jiang, Guangcheng, et al. &quot;GnRH antagonists: a new generation of long acting analogues incorporating p-ureido-phenylalanines at positions 5 and 6.&quot;&nbsp;</span><i style=”font-family: Arial, sans-serif; font-size: 13px;”>Journal of medicinal chemistry</i><span style=”font-family: Arial, sans-serif; font-size: 13px;”>&nbsp;44.3 (2001): 453-467.<br />
2.</span><span style=”font-family: Arial, sans-serif; font-size: 13px;”>Broqua, Pierre, et al. &quot;Pharmacological profile of a new, potent, and long-acting gonadotropin-releasing hormone antagonist: degarelix.&quot;&nbsp;</span><i style=”font-family: Arial, sans-serif; font-size: 13px;”>Journal of Pharmacology and Experimental Therapeutics</i><span style=”font-family: Arial, sans-serif; font-size: 13px;”>&nbsp;301.1 (2002): 95-102.<br />
3.</span><span style=”font-family: Arial, sans-serif; font-size: 13px;”>Lebovic, Dan I., et al. &quot;PPAR-gamma receptor ligand induces regression of endometrial explants in baboons: a prospective, randomized, placebo-and drug-controlled study.&quot;&nbsp;</span><i style=”font-family: Arial, sans-serif; font-size: 13px;”>Fertility and sterility</i><span style=”font-family: Arial, sans-serif; font-size: 13px;”>&nbsp;88.4 (2007): 1108-1119.</span>

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