Ganoderic Acid C1

• CAT Number: I027938
• CAS Number: 95311-97-0
• Molecular Formula: C30H42O7
• Molecular Weight: 514.65
• Purity: ≥95%
• Synonyms: Ganoderic Acid C1; Ganoderic-Acid C1; Ganoderic Acid-C1; Ganoderic-Acid-C1
• Target: Disease Research Fields
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
• IUPAC Name: (2R,6R)-6-((5R,7S,10S,13R,14R,17R)-7-hydroxy-4,4,10,13,14-pentamethyl-3,11,15-trioxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methyl-4-oxoheptanoic acid
• InChI: InChI=1S/C30H42O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,32H,8-14H2,1-7H3,(H,36,37)/t15-,16-,18-,19+,21+,28+,29-,30+/m1/s1
• InChIKey: YTVGSCZIHGRVAV-NJNFCIENSA-N
• SMILES: C[C@]12C3=C([C@]4(C)[C@@]([H])(C[C@@H]3O)C(C(CC4)=O)(C)C)C(C[C@]1(C)[C@]([H])(CC2=O)[C@H](C)CC(C[C@H](C(O)=O)C)=O)=O

Ganoderic acid C1 (Cat.No:I027938) is a triterpenoid that has been found in G. lucidum and has diverse biological activities. It inhibits angiotensin-converting enzyme. Ganoderic acid C1 also inhibits HIV-1 protease with an IC50 value of 180 µM. It reduces the proliferation of murine Lewis lung carcinoma cells but not murine Meth-A sarcoma cells. Ganoderic acid C1 (20 µg/ml) inhibits LPS-induced NF-κB phosphorylation and production of TNF-α in RAW 264.7 cells, as well as in peripheral blood mononuclear cells (PBMCs) isolated from patients with asthma.

Reference

1: Liu C, Yang N, Song Y, Wang L, Zi J, Zhang S, Dunkin D, Busse P, Weir D, Tversky J, Miller RL, Goldfarb J, Zhan J, Li XM. Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients. Int Immunopharmacol. 2015 Aug;27(2):224-31. doi: 10.1016/j.intimp.2015.05.018. Epub 2015 May 21. PMID: 26004313; PMCID: PMC4635663.
2: Liu C, Dunkin D, Lai J, Song Y, Ceballos C, Benkov K, Li XM. Anti- inflammatory Effects of Ganoderma lucidum Triterpenoid in Human Crohn’s Disease Associated with Downregulation of NF-κB Signaling. Inflamm Bowel Dis. 2015 Aug;21(8):1918-25. doi: 10.1097/MIB.0000000000000439. PMID: 25993687; PMCID: PMC4509964.
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7: el-Mekkawy S, Meselhy MR, Nakamura N, Tezuka Y, Hattori M, Kakiuchi N, Shimotohno K, Kawahata T, Otake T. Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. Phytochemistry. 1998 Nov;49(6):1651-7. doi: 10.1016/s0031-9422(98)00254-4. PMID: 9862140.
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