GANT58

• CAT Number: I004422
• CAS Number: 64048-12-0
• Molecular Formula: C₂₄H₁₆N₄S
• Molecular Weight: 392.48
• Purity: ≥95%
• Synonyms: 4-(2,4,5-tripyridin-4-ylthiophen-3-yl)pyridine
• Target: Gli
• Solubility: 25 mM in DMSO;25 mM in ethanol
• Storage: Store at -20°C
• IC50: 5 uM
• InChI: InChI=1S/C24H16N4S/c1-9-25-10-2-17(1)21-22(18-3-11-26-12-4-18)24(20-7-15-28-16-8-20)29-23(21)19-5-13-27-14-6-19/h1-16H
• InChIKey: USWLOKMMUTWFMD-UHFFFAOYSA-N
• SMILES: C1=CN=CC=C1C2=C(SC(=C2C3=CC=NC=C3)C4=CC=NC=C4)C5=CC=NC=C5

GANT58 (Cat.No:I004422) is a small molecule inhibitor that targets the GLI transcription factors, key components of the Hedgehog signaling pathway. It has been studied for its potential in inhibiting the growth of various cancer cells, including those resistant to conventional therapies. GANT58 shows promise as a therapeutic agent for Hedgehog pathway-dependent cancers.

Reference

[1]. Lauth et al (2007) Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc.Natl.Acad.Sci. 104 8455.
[2]. Joo et al (2009) GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors. PLoS ONE 4 7608.
[3]. Hassounah NB, Bunch TA, McDermott KM.,Molecular pathways: the role of primary cilia in cancer progression and therapeutics with a focus on Hedgehog signaling.,Clin Cancer Res. 2012 May 1;18(9):2429-35. Epub 2012 Mar 13.
[4]. Stanton BZ, Peng LF.,Small-molecule modulators of the Sonic Hedgehog signaling pathway.,Mol Biosyst. 2010 Jan;6(1):44-54. Epub 2009 Aug 27.
[5]. Katoh Y, Katoh M.,Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.,Curr Mol Med. 2009 Sep;9(7):873-86.
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