GANT61

• CAT Number: I003758
• CAS Number: 500579-04-4
• Molecular Formula: C27H35N5
• Molecular Weight: 429.60
• Purity: ≥95%
• Synonyms: 2-[[3-[[2-(dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline
• Target: Autophagy
• Solubility: DMSO: ≤ 17.6 mg/mL
• Storage: Store at -20°C
• IC50: 5-15 uM (inhibited clonogenic survival of human colon carcinoma cell lines)
• InChI: InChI=1S/C27H35N5/c1-29(2)25-12-7-5-10-23(25)20-31-18-9-19-32(27(31)22-14-16-28-17-15-22)21-24-11-6-8-13-26(24)30(3)4/h5-8,10-17,27H,9,18-21H2,1-4H3
• InChIKey: KVQOGDQTWWCZFX-UHFFFAOYSA-N
• SMILES: CN(C)C1=CC=CC=C1CN2CCCN(C2C3=CC=NC=C3)CC4=CC=CC=C4N(C)C

GANT61(CAT: I003758) is a small molecule inhibitor that targets the Hedgehog (Hh) signaling pathway. It specifically inhibits the transcriptional activity of Glioma-associated oncogene homolog (Gli) proteins, which are key effectors of the Hh pathway. By blocking Gli-mediated transcription, GANT61 suppresses the expression of downstream target genes involved in cell proliferation and survival. This pharmacologic action has significant implications in cancer research, as dysregulated Hh signaling is associated with various cancers, including medulloblastoma, basal cell carcinoma, and pancreatic cancer.