Gap19

• CAT Number: P000298
• CAS Number: 1507930-57-5
• Molecular Formula: C55H96N14O13
• Molecular Weight: 1161.44
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: CCC(C)C(NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(N)CCCCN)C(C)CC)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCCN)C(O)=O

Gap19 is a nonapeptide derived from the cytoplasmic loop (CL) of Cx43 and acts as a selective connexin 43 (Cx43) hemichannel blocker. Gap19 blocks Cx43 hemichannels without inhibiting gap junctions (GJs) at IC50 of 6.5 μM when applied intracellulary.

Reference

[1] Nan Wang, et al. Basic Res Cardiol. 2013 Jan;108(1):309.