Gatifloxacin hydrochloride

• CAT Number: I000814
• CAS Number: 121577-32-0
• Molecular Formula: C19H23ClFN3O4
• Molecular Weight: 411.86
• Purity: ≥95%
• Synonyms: 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid;hydrochloride
• Target: Antibiotic
• Solubility: DMSO 7 mg/Ml; Water <1 mg/mL
• Storage: Store at -20C

Gatifloxacin hydrochloride（Cat No.:I000814）is a fourth-generation fluoroquinolone antibiotic used to treat a variety of bacterial infections, particularly respiratory and urinary tract infections, as well as eye infections. It inhibits bacterial DNA gyrase and topoisomerase IV, enzymes crucial for DNA replication and cell division, leading to bacterial cell death. Gatifloxacin is effective against both gram-positive and gram-negative pathogens, including resistant strains. Available in oral, injectable, and ophthalmic forms, it provides flexibility in treatment. Its broad-spectrum activity and efficacy make Gatifloxacin hydrochloride a valuable option in managing complex bacterial infections.

Reference

[1]. Fukuda, H., S. Hori, and K. Hiramatsu, Antibacterial activity of gatifloxacin (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus. Antimicrob Agents Chemother, 1998. 42(8): p. 1917-22.

[2]. Jensen, H., et al., Comparison of ophthalmic gatifloxacin 0.3% and ciprofloxacin 0.3% in healing of corneal ulcers associated with Pseudomonas aeruginosa-induced ulcerative keratitis in rabbits. J Ocul Pharmacol Ther, 2005. 21(1): p. 36-43.

[3]. Cheung, O., et al., Gatifloxacin-induced hepatotoxicity and acute pancreatitis. Ann Intern Med, 2004. 140(1): p. 73-4.

[4]. Fteha, A., et al., Gatifloxacin induced torsades de pointes. Pacing Clin Electrophysiol, 2004. 27(10): p. 1449-50.