Gatifloxacin sesquihydrate

• CAT Number: M035006
• CAS Number: 180200-66-2
• Molecular Formula: C38H50F2N6O11
• Molecular Weight: 804.84
• Purity: ≥95%
• Target: Cell Cycle/DNA Damage
• Storage: -20°C
• IUPAC Name: 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid;trihydrate
• InChI: InChI=1S/2C19H22FN3O4.3H2O/c2*1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26;;;/h2*7,9-11,21H,3-6,8H2,1-2H3,(H,25,26);3*1H2
• InChIKey: RMJMZKDEVNTXHE-UHFFFAOYSA-N
• SMILES: CC1CN(CCN1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F.CC1CN(CCN1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F.O.O.O

Gatifloxacin sesquihydrate（Cat No.:M035006）is a pharmaceutical-grade compound used primarily in the treatment of bacterial infections. As a fluoroquinolone antibiotic, it inhibits bacterial DNA gyrase and topoisomerase IV, disrupting DNA replication and transcription, ultimately leading to bacterial cell death. This sesquihydrate form is a stable version of gatifloxacin, offering enhanced solubility and bioavailability. Gatifloxacin sesquihydrate is commonly used in ophthalmic formulations for the treatment of eye infections and may also be applied in oral preparations for systemic bacterial infections. It is effective against a wide spectrum of Gram-positive and Gram-negative bacteria.

Reference

Wolfson, John S., and David C. Hooper. /The Fluoroquinolones: Structures, Mechanisms of Action and Resistance, and Spectra of Activity in Vitro./ American Society for Microbiology 4th ser. 28 (1985): 581-86.