For research use only. Not for therapeutic Use.
Selective antagonist of human protease activated receptor 2 (PAR2) (IC50: 2 micromolar); reversibly inhibits PAR2 activation by both proteases and other PAR2 agonists
| Catalog Number | I027965 |
| CAS Number | 1252806-86-2 |
| Molecular Formula | C32H44N4O4 |
| Purity | ≥95% |
| IUPAC Name | N-[(2S)-3-cyclohexyl-1-[[(2S)-3-methyl-1-oxo-1-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpentan-2-yl]amino]-1-oxopropan-2-yl]-1,2-oxazole-5-carboxamide |
| InChI | InChI=1S/C32H44N4O4/c1-3-22(2)28(31(39)36-19-16-32(17-20-36)15-13-24-11-7-8-12-25(24)32)35-29(37)26(21-23-9-5-4-6-10-23)34-30(38)27-14-18-33-40-27/h7-8,11-12,14,18,22-23,26,28H,3-6,9-10,13,15-17,19-21H2,1-2H3,(H,34,38)(H,35,37)/t22?,26-,28-/m0/s1 |
| SMILES | CCC(C)[C@@H](C(=O)N1CCC2(CCC3=CC=CC=C32)CC1)NC(=O)[C@H](CC4CCCCC4)NC(=O)C5=CC=NO5 |
| Reference | GD Barry et al. Novel agonist and antagonist for human protease activated receptor 2. J. Med. Chem. 2010, 53, 7428-7440. |
