For research use only. Not for therapeutic Use.
GBR-12935 HCl (Cat No.: I006936) is a selective dopamine reuptake inhibitor that targets the dopamine transporter (DAT) with high affinity, without significantly affecting serotonin or norepinephrine transporters. It is widely used in neuroscience research to study dopaminergic signaling, particularly in relation to neuropsychiatric and neurodegenerative disorders such as Parkinson’s disease, schizophrenia, and addiction. GBR-12935 HCl helps explore dopamine transporter function, neurotoxicity, and the effects of psychostimulants. Its specificity and potency make it a valuable tool for investigating dopamine-related pathways and drug development.
| CAS Number | 67469-81-2 (HCl) |
| Synonyms | GBR12935; GBR 12935; GBR-12935; GBR-12935 HCl; GBR-12935 hydrochloride;1-(2-(benzhydryloxy)ethyl)-4-(3a-phenylpropyl)piperazine dihydrochloride |
| Molecular Formula | C28H36Cl2N2O |
| Purity | ≥95% |
| Target | Dopamine Transporter |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| IUPAC Name | 1-(2-benzhydryloxyethyl)-4-(3-phenylpropyl)piperazine;dihydrochloride |
| InChI | InChI=1S/C28H34N2O.2ClH/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27;;/h1-9,11-12,14-17,28H,10,13,18-24H2;2*1H |
| InChIKey | NQWRSILGEXNJIT-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=CC=C3)C4=CC=CC=C4.Cl.Cl |
| Reference | </br>1:Zhu J, Green T, Bardo MT, Dwoskin LP. Environmental enrichment enhances sensitization to GBR 12935-induced activity and decreases dopamine transporter function in the medial prefrontal cortex. Behav Brain Res. 2004 Jan 5;148(1-2):107-17. PubMed PMID: 14684252. |
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