For research use only. Not for therapeutic Use.
Gcase activator 2 (compound 14), a pyrrolo[2,3-b]pyrazine, is alos a β-Glucocerebrosidase (GCase) activator (EC50=3.8 μM). Gcase activator 2 induces GCase dimerizatio (both K-type and V-type). And Gcase activator 2 has low metabolic clearance in human and mouse[1].
Gcase activator 2 has low metabolic clearance in human and mouse with CL values of 10 and 12 μL/min/mg, respectively[1].
| Catalog Number | I041060 |
| CAS Number | 2759897-35-1 |
| Synonyms | 1-[4-[2-(4-methoxyphenyl)-5-methylpyrrolo[2,3-b]pyrazin-6-yl]piperidin-1-yl]ethanone |
| Molecular Formula | C21H24N4O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H24N4O2/c1-14(26)25-10-8-16(9-11-25)20-12-18-21(24(20)2)22-13-19(23-18)15-4-6-17(27-3)7-5-15/h4-7,12-13,16H,8-11H2,1-3H3 |
| InChIKey | HEAGFUMRBLFGAD-UHFFFAOYSA-N |
| SMILES | CC(=O)N1CCC(CC1)C2=CC3=NC(=CN=C3N2C)C4=CC=C(C=C4)OC |
| Reference | [1]. Benz J, et al. Novel β-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization. Angew Chem Int Ed Engl. 2021 Mar 1;60(10):5436-5442. |
