GCase modulator-1

• CAT Number: I040562
• CAS Number: 796079-91-9
• Molecular Formula: C22H18N4
• Molecular Weight: 338.41
• Purity: ≥95%
• Synonyms: 4-(3,4-dihydro-1H-isoquinolin-2-yl)-2-pyridin-3-ylquinazoline
• InChI: InChI=1S/C22H18N4/c1-2-7-18-15-26(13-11-16(18)6-1)22-19-9-3-4-10-20(19)24-21(25-22)17-8-5-12-23-14-17/h1-10,12,14H,11,13,15H2
• InChIKey: JKPCEULHIROZLA-UHFFFAOYSA-N
• SMILES: C1CN(CC2=CC=CC=C21)C3=NC(=NC4=CC=CC=C43)C5=CN=CC=C5

GCase modulator-1 (compound 9g), a derivative of Quinazoline, is a modulator of GCase (Glucosidase) (AC50=2.23 μM)[1].

Reference

[1]. Zheng J, et al. Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. J Med Chem. 2019 Feb 14;62(3):1218-1230.
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