GCN2-IN-1

• CAT Number: I020177
• CAS Number: 1448693-69-3
• Molecular Formula: C₁₉H₁₈N₁₀O
• Molecular Weight: 402.41
• Purity: ≥95%
• Target: Eukaryotic Initiation Factor (eIF)
• IUPAC Name: 3-(1H-indazol-6-yl)-N-[1-(oxan-4-yl)pyrazol-4-yl]triazolo[4,5-d]pyrimidin-5-amine
• InChI: InChI=1S/C19H18N10O/c1-2-15(7-16-12(1)8-21-25-16)29-18-17(26-27-29)10-20-19(24-18)23-13-9-22-28(11-13)14-3-5-30-6-4-14/h1-2,7-11,14H,3-6H2,(H,21,25)(H,20,23,24)
• InChIKey: CFNFLNGJQOHNPR-UHFFFAOYSA-N
• SMILES: C1COCCC1N2C=C(C=N2)NC3=NC=C4C(=N3)N(N=N4)C5=CC6=C(C=C5)C=NN6

GCN2-IN-1（Cat No.:I020177）is an investigational small molecule designed to inhibit GCN2 (General Control Nonderepressible 2), a protein kinase involved in cellular stress responses, particularly under conditions of amino acid deprivation. GCN2 plays a key role in regulating protein synthesis and cell survival during stress, such as nutrient scarcity. By inhibiting GCN2, GCN2-IN-1 may enhance the effectiveness of cancer treatments by disrupting the stress response in tumor cells, making them more susceptible to chemotherapy or radiation. Early research shows promising results, but further clinical studies are needed to assess its safety, efficacy, and therapeutic potential.