For research use only. Not for therapeutic Use.
GCN2-IN-7（Cat No.:I043117）is a small molecule inhibitor that targets GCN2 (General Control Nonderepressible 2), a kinase involved in the integrated stress response (ISR). GCN2 plays a key role in regulating cellular responses to amino acid deprivation and other stress signals by phosphorylating the eukaryotic initiation factor 2 (eIF2α). By inhibiting GCN2, GCN2-IN-7 disrupts this stress response pathway, making it a valuable tool in studying cellular stress mechanisms and protein synthesis regulation. This compound holds potential for therapeutic applications in diseases associated with the dysregulation of stress responses, including cancer and neurodegenerative disorders.
| CAS Number | 2396465-33-9 |
| Synonyms | (1R,3R)-3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethylcyclopentane-1-carboxamide |
| Molecular Formula | C22H23BrN8OS |
| Purity | ≥95% |
| IUPAC Name | (1R,3R)-3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethylcyclopentane-1-carboxamide |
| InChI | InChI=1S/C22H23BrN8OS/c1-12-28-29-19(33-12)13-4-6-15(7-5-13)31-18-16(17(23)30-31)11-25-21(27-18)26-14-8-9-22(2,10-14)20(32)24-3/h4-7,11,14H,8-10H2,1-3H3,(H,24,32)(H,25,26,27)/t14-,22-/m1/s1 |
| InChIKey | ASGMFNBUXDJWJJ-JLCFBVMHSA-N |
| SMILES | CC1=NN=C(S1)C2=CC=C(C=C2)N3C4=NC(=NC=C4C(=N3)Br)N[C@@H]5CC[C@@](C5)(C)C(=O)NC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
