GDC-0032

• CAT Number: I001112
• CAS Number: 1282512-48-4
• Molecular Formula: C₂₄H₂₈N₈O₂
• Molecular Weight: 460.53
• Purity: ≥95%
• Synonyms: GDC-0032
• Target: PI3K
• Solubility: 10 mM in DMSO
• Storage: 3 years -20C powder
• IC50: 0.29 nM/0.12 nM /0.97 nM(PI3Kα/δ/γ)
• IUPAC Name: 2-methyl-2-[4-[2-(5-methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanamide
• InChI: InChI=1S/C24H28N8O2/c1-14(2)32-22(27-15(3)29-32)19-13-30-8-9-34-20-10-16(6-7-18(20)21(30)28-19)17-11-26-31(12-17)24(4,5)23(25)33/h6-7,10-14H,8-9H2,1-5H3,(H2,25,33)
• InChIKey: BEUQXVWXFDOSAQ-UHFFFAOYSA-N
• SMILES: CC1=NN(C(=N1)C2=CN3CCOC4=C(C3=N2)C=CC(=C4)C5=CN(N=C5)C(C)(C)C(=O)N)C(C)C

GDC-0032（Cat No.:I001112）is an investigational oral inhibitor of the phosphoinositide 3-kinase (PI3K) pathway, specifically targeting the PI3K-alpha isoform. This pathway plays a crucial role in regulating cell growth, survival, and metabolism, and its dysregulation is often implicated in cancer. By inhibiting PI3K-alpha, GDC-0032 aims to suppress tumor cell proliferation and survival, making it a potential treatment for cancers driven by mutations in the PI3K pathway, such as breast cancer. Clinical studies have shown promise in combination with other therapies, although further trials are required to confirm its safety and effectiveness.

Reference

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