For research use only. Not for therapeutic Use.
GDC-0349（Cat No.:I000774）is a potent and selective inhibitor of the mechanistic target of rapamycin (mTOR), specifically targeting mTORC1 and mTORC2 complexes. By inhibiting mTOR signaling, GDC-0349 disrupts key cellular processes, such as protein synthesis, cell growth, and survival, making it a valuable compound in cancer research. It has demonstrated antitumor activity by reducing tumor cell proliferation and inducing apoptosis, particularly in cancers with dysregulated mTOR pathways. GDC-0349 is being investigated for its potential to treat various solid tumors and hematologic malignancies, offering promise as a targeted cancer therapy.
| Catalog Number | I000774 |
| CAS Number | 1207360-89-1 |
| Synonyms | 1-ethyl-3-[4-[4-[(3S)-3-methylmorpholin-4-yl]-7-(oxetan-3-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]phenyl]urea |
| Molecular Formula | C₂₄H₃₂N₆O₃ |
| Purity | ≥95% |
| Target | Autophagy |
| Solubility | DMSO 90 mg/ml |
| Storage | 3 years -20℃ powder |
| IC50 | 3.8 nM |
| IUPAC Name | 1-ethyl-3-[4-[4-[(3S)-3-methylmorpholin-4-yl]-7-(oxetan-3-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]phenyl]urea |
| InChI | InChI=1S/C24H32N6O3/c1-3-25-24(31)26-18-6-4-17(5-7-18)22-27-21-12-29(19-14-33-15-19)9-8-20(21)23(28-22)30-10-11-32-13-16(30)2/h4-7,16,19H,3,8-15H2,1-2H3,(H2,25,26,31)/t16-/m0/s1 |
| InChIKey | RGJOJUGRHPQXGF-INIZCTEOSA-N |
| SMILES | CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(CCN(C3)C4COC4)C(=N2)N5CCOC[C@@H]5C |
| Reference | </br>1:Autophagy induction contributes to GDC-0349 resistance in head and neck squamous cell carcinoma (HNSCC) cells. Zhou Y, Peng Y, Tang H, He X, Wang Z, Hu D, Zhou X.Biochem Biophys Res Commun. 2016 Aug 19;477(2):174-80. doi: 10.1016/j.bbrc.2016.06.039. Epub 2016 Jun 10. PMID: 27291151 </br>2:Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349. Pei Z, Blackwood E, Liu L, Malek S, Belvin M, Koehler MF, Ortwine DF, Chen H, Cohen F, Kenny JR, Bergeron P, Lau K, Ly C, Zhao X, Estrada AA, Truong T, Epler JA, Nonomiya J, Trinh L, Sideris S, Lesnick J, Bao L, Vijapurkar U, Mukadam S, Tay S, Deshmukh G, Chen YH, Ding X, Friedman LS, Lyssikatos JP.ACS Med Chem Lett. 2012 Nov 29;4(1):103-7. doi: 10.1021/ml3003132. eCollection 2013 Jan 10. PMID: 24900569 Free PMC Article |
