For research use only. Not for therapeutic Use.
GDC-0941 (Pictilisib)（Cat No.:I006942）is a potent, selective inhibitor of class I phosphoinositide 3-kinase (PI3K), a critical component of the PI3K/Akt/mTOR signaling pathway involved in cell growth, survival, and metabolism. By inhibiting PI3K, GDC-0941 suppresses downstream signaling, leading to reduced proliferation and increased apoptosis in cancer cells. It has shown efficacy in preclinical and clinical studies for various cancers, including breast, lung, and prostate cancers. GDC-0941 is a valuable tool in oncology research, providing insights into PI3K-targeted therapies for tumors with dysregulated PI3K signaling.
| Catalog Number | I006942 |
| CAS Number | 957054-30-7 (free base); 957054-33-0 (mesylate). |
| Synonyms | ;4-(2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine |
| Molecular Formula | C23H27N7O3S2 |
| Purity | ≥95% |
| Target | PI3K inhibitor |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| IUPAC Name | 4-[2-(1H-indazol-4-yl)-6-[(4-methylsulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine |
| InChI | InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27) |
| InChIKey | LHNIIDJUOCFXAP-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6 |
| Reference | </br>1:Ehrhardt M, Craveiro RB, Holst MI, Pietsch T, Dilloo D. The PI3K inhibitor GDC-0941 displays promising in vitro and in vivo efficacy for targeted medulloblastoma therapy. Oncotarget. 2015 Jan 20;6(2):802-13. PubMed PMID: 25596739. |
