GeA-69

• CAT Number: I019116
• CAS Number: 2143475-98-1
• Molecular Formula: C₂₀H₁₆N₂O
• Molecular Weight: 300.35
• Purity: ≥95%

GeA-69(CAT: I019116) is a compound known as a selective, allosteric inhibitor of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14). It specifically targets macrodomain 2 of PARP14, a protein involved in various cellular processes, including DNA repair and regulation of gene expression. By inhibiting PARP14, GeA-69 interferes with its enzymatic activity and disrupts its cellular functions. This compound holds promise as a potential therapeutic agent for conditions in which PARP14 is implicated, such as cancer and inflammatory diseases.

Reference

[1]. Schuller M, et al. Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14. ACS Chem Biol. 2017 Nov 17;12(11):2866-2874.