Gea 968

• CAT Number: I027996
• CAS Number: 50333-29-4
• Molecular Formula: C16H25N3O2
• Molecular Weight: 291.39
• Purity: 98%
• Synonyms: Gea 968; Gea-968; Gea968
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: N-[2-(diethylamino)acetyl]-2-(2,6-dimethylanilino)acetamide
• InChI: InChI=1S/C16H25N3O2/c1-5-19(6-2)11-15(21)18-14(20)10-17-16-12(3)8-7-9-13(16)4/h7-9,17H,5-6,10-11H2,1-4H3,(H,18,20,21)
• InChIKey: GDIMEORILKFOSR-UHFFFAOYSA-N
• SMILES: CCN(CC)CC(=O)NC(=O)CNC1=C(C=CC=C1C)C

GEA 968（Cat No.:I027996）is a selective, potent inhibitor of the enzyme phosphodiesterase 4 (PDE4), which plays a key role in regulating cellular levels of cyclic AMP (cAMP). By inhibiting PDE4, GEA 968 increases cAMP concentrations, leading to the modulation of inflammatory and immune responses. This mechanism makes GEA 968 a promising candidate for the treatment of inflammatory diseases such as chronic obstructive pulmonary disease (COPD), asthma, and other conditions involving excessive inflammation. Preclinical studies have shown its potential to reduce symptoms and improve lung function, with ongoing clinical trials evaluating its safety and efficacy.

Reference

1: Courtney KR. Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA. J Pharmacol Exp Ther. 1975 Nov;195(2):225-36. PMID: 1081138.