Gedatolisib (PKI-587)

• CAT Number: I000718
• CAS Number: 1197160-78-3
• Molecular Formula: C32H41N9O4
• Molecular Weight: 615.73
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: CN(C)C1CCN(CC1)C(=O)C2=CC=C(C=C2)NC(=O)NC3=CC=C(C=C3)C4=NC(=NC(=N4)N5CCOCC5)N6CCOCC6

Gedatolisib (PF-05212384, PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ and mTOR with IC50 of 0.4 nM, 5.4 nM and 1.6 nM in cell-free assays, respectively. Phase 2.

Reference

[1] Venkatesan AM, et al. J Med Chem. 2010, 53(6), 2636-2645.
[2] Gedaly R, et al. J Surg Res. 2011, doi.org/10.1016/j.jss.2011.10.045.