Gefitinib-d3

• CAT Number: S000316
• CAS Number: 1173976-40-3
• Molecular Formula: C22H21D3ClFN4O3
• Molecular Weight: 449.92
• Purity: ≥95%
• IUPAC Name: N-(3-chloro-4-fluorophenyl)-6-(3-morpholin-4-ylpropoxy)-7-(trideuteriomethoxy)quinazolin-4-amine
• InChI: InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)/i1D3
• InChIKey: XGALLCVXEZPNRQ-FIBGUPNXSA-N
• SMILES: COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4

Gefitinib-d3（Cat No.:S000316） is a deuterated version of gefitinib, where three hydrogen atoms are replaced with deuterium. Gefitinib is a tyrosine kinase inhibitor used primarily to treat non-small cell lung cancer (NSCLC) by blocking the epidermal growth factor receptor (EGFR) signaling pathways that promote tumor growth. The incorporation of deuterium enhances the stability and traceability of gefitinib, facilitating more accurate pharmacokinetic and metabolic studies.