For research use only. Not for therapeutic Use.
Gemifloxacin Mesylate（Cat No.:I002618）is a broad-spectrum fluoroquinolone antibiotic used to treat respiratory tract infections, particularly acute bacterial exacerbations of chronic bronchitis and community-acquired pneumonia. It works by inhibiting bacterial DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication, transcription, and repair. Effective against a variety of Gram-positive and Gram-negative pathogens, including Streptococcus pneumoniae and Haemophilus influenzae, gemifloxacin offers high tissue penetration in lung tissues. Known for its potency and safety profile, it is a valuable treatment option for respiratory infections resistant to other antibiotics.
| Catalog Number | I002618 |
| CAS Number | 210353-53-0 |
| Synonyms | LB 20304a;SB 265805S |
| Molecular Formula | C18H20FN5O4 • CH3SO3H |
| Purity | ≥95% |
| Solubility | DMSO:30mg/mL |
| Storage | Store at -20°C |
| IUPAC Name | 7-[(4Z)-3-(aminomethyl)-4-methoxyiminopyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid;methanesulfonic acid |
| InChI | InChI=1S/C18H20FN5O4.CH4O3S/c1-28-22-14-8-23(6-9(14)5-20)17-13(19)4-11-15(25)12(18(26)27)7-24(10-2-3-10)16(11)21-17;1-5(2,3)4/h4,7,9-10H,2-3,5-6,8,20H2,1H3,(H,26,27);1H3,(H,2,3,4)/b22-14+; |
| InChIKey | JIYMVSQRGZEYAX-CWUUNJJBSA-N |
| SMILES | CO/N=C/1\CN(CC1CN)C2=C(C=C3C(=O)C(=CN(C3=N2)C4CC4)C(=O)O)F.CS(=O)(=O)O |
| Reference | </br>1:Ingestion of the anti-bacterial agent, gemifloxacin mesylate, leads to increased gst activity and peroxidation products in hemolymph of Galleria mellonella l. (lepidoptera: pyralidae). Erdem M, Küçük C, Büyükgüzel E, Büyükgüzel K.Arch Insect Biochem Physiol. 2016 Dec;93(4):202-209. doi: 10.1002/arch.21352. Epub 2016 Sep 2. PMID: 27588824 </br>2:Structural elucidation of gemifloxacin mesylate degradation product. Paim CS, Führ F, Martins MT, Gnoatto S, Bajerski L, Garcia CV, Steppe M, Schapoval EE.Biomed Chromatogr. 2016 Mar;30(3):459-65. doi: 10.1002/bmc.3569. Epub 2015 Sep 2. PMID: 26205148 </br>3:Spectrophotometric method for the determination of Gemifloxacin mesylate in pure and tablet dosage form. Hassan SS, Hayat U, Tariq I, Ahmad I, Hayat MM, Uzair M, Ansari MT.Pak J Pharm Sci. 2014 Sep;27(5):1171-4. PMID: 25176374 </br>4:HPTLC method for direct determination of gemifloxacin mesylate in human plasma. El-Koussi WM, Atia NN, Mahmoud AM, El-Shabouri SR.J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Sep 15;967:98-101. doi: 10.1016/j.jchromb.2014.07.004. Epub 2014 Jul 11. PMID: 25086419 </br>5:Highly selective colorimetric method to determine gemifloxacin mesylate in the presence of a synthetic impurity. Paim CS, Führ F, Miron DS, Steppe M, Schapoval EE.J AOAC Int. 2014 Jan-Feb;97(1):94-8. PMID: 24672864 </br>6:Spectrofluorimetric determination of gemifloxacin mesylate and linezolid in pharmaceutical formulations: Application of quinone-based fluorophores and enhanced native fluorescence. Moussa BA, Mahrouse MA, Hassan MA, Fawzy MG.Acta Pharm. 2014 Mar;64(1):15-28. doi: 10.2478/acph-2014-0005. PMID: 24670349 </br>7:Spectrophotometric determination of gemifloxacin mesylate, moxifloxacin hydrochloride, and enrofloxacin in pharmaceutical formulations using Acid dyes. Gouda AA, Amin AS, El-Sheikh R, Yousef AG.J Anal Methods Chem. 2014;2014:286379. doi: 10.1155/2014/286379. Epub 2014 Jan 22. PMID: 24587941 Free PMC Article</br>8:Gemifloxacin mesylate (GFM): dissolution test based on in vivo data. Paim CS, Verlindo de Araújo B, Volpato NM, Steppe M, Schapoval EE.Drug Dev Ind Pharm. 2015 Apr;41(4):567-72. doi: 10.3109/03639045.2014.884128. Epub 2014 Feb 12. PMID: 24517572 </br>9:Two validated spectrofluorometric methods for determination of gemifloxacin mesylate in tablets and human plasma. Atia NN, Mahmoud AM, El-Shabouri SR, El-Koussi WM.Int J Anal Chem. 2013;2013:137279. doi: 10.1155/2013/137279. Epub 2013 May 16. PMID: 23762060 Free PMC Article</br>10:Spectrofluorimetric analysis of gemifloxacin mesylate in pharmaceutical formulations. Al-Tamimi SA, Alarfaj NA, Aly FA, Al-Mohaimeed AM.Luminescence. 2014 Mar;29(2):127-31. doi: 10.1002/bio.2515. Epub 2013 May 17. PMID: 23681953 |
