Geniposide

• CAT Number: A000189
• CAS Number: 24512-63-8
• Molecular Formula: C17H24O10
• Molecular Weight: 388.37
• Purity: ≥95%
• Storage: -20°C
• InChI: 1S/C17H24O10/c1-24-15(23)9-6-25-16(11-7(4-18)2-3-8(9)11)27-17-14(22)13(21)12(20)10(5-19)26-17/h2,6,8,10-14,16-22H,3-5H2,1H3/t8-,10-,11-,12-,13+,14-,16+,17+/m1/s1
• InChIKey: IBFYXTRXDNAPMM-BVTMAQQCSA-N
• SMILES: COC(=O)C1=COC(C2C1CC=C2CO)OC3C(C(C(C(O3)CO)O)O)O

Geniposide is a natural product isolated from the fruit of Gerdenia. It was found to induce increased activity of phase II detoxifying enzymes, inhibit tumor promotion, and induce apoptosis in rat C6 glioma cells. (Source: http://www.lktlabs.com/products/Geniposide-816-12.html).

Reference

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of geniposide in HSC-3 human oral squamous cell carcinoma cells. Exp Ther Med.
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2: Shi F, Pan H, Li Y, Huang L, Wu Q, Lu Y. A sensitive LC-MS/MS method for
simultaneous quantification of geniposide and its active metabolite genipin in
rat plasma and its application to a pharmacokinetic study. Biomed Chromatogr.
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3: Gao XC, Tong Y. [Effect of wintergreen oil on in vitro transdermal permeation
of osthole and geniposide]. Zhongguo Zhong Yao Za Zhi. 2017 Apr;42(7):1338-1343.
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4: Shan M, Yu S, Yan H, Guo S, Xiao W, Wang Z, Zhang L, Ding A, Wu Q, Li SFY. A
Review on the Phytochemistry, Pharmacology, Pharmacokinetics and Toxicology of
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5: Yu J, Guo X, Zhang Q, Peng Y, Zheng J. Metabolite profile analysis and
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6: Yu B, Shen Y, Qiao J, Cui Q. Geniposide attenuates Staphylococcus
aureus-induced pneumonia in mice by inhibiting NF-κB activation. Microb Pathog.
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7: Huang B, Chen P, Huang L, Li S, Zhu R, Sheng T, Yu W, Chen Z, Wang T.
Geniposide Attenuates Post-Ischaemic Neurovascular Damage via GluN2A/AKT/
ERK-Dependent Mechanism. Cell Physiol Biochem. 2017;43(2):705-716. doi:
10.1159/000480657. Epub 2017 Sep 22. PubMed PMID: 28957809.

8: Jiang H, Ma Y, Yan J, Liu J, Li L. Geniposide promotes autophagy to inhibit
insulin resistance in HepG2 cells via P62/NF‑κB/GLUT‑4. Mol Med Rep. 2017
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9: Tian J, Zhu J, Yi Y, Li C, Zhang Y, Zhao Y, Pan C, Xiang S, Li X, Li G, Newman
JW, Feng X, Liu J, Han J, Wang L, Gao Y, La Frano MR, Liang A. Dose-related liver
injury of Geniposide associated with the alteration in bile acid synthesis and
transportation. Sci Rep. 2017 Aug 21;7(1):8938. doi: 10.1038/s41598-017-09131-2.
PubMed PMID: 28827769; PubMed Central PMCID: PMC5566417.

10: Rong YP, Huang HT, Liu JS, Wei L. Protective Effects of Geniposide on Hepatic
Ischemia/Reperfusion Injury. Transplant Proc. 2017 Jul – Aug;49(6):1455-1460.
doi: 10.1016/j.transproceed.2017.02.063. PubMed PMID: 28736023.