Genistein 8-c-glucoside

• CAT Number: I018217
• CAS Number: 66026-80-0
• Molecular Formula: C₂₁H₂₀O₁₀
• Molecular Weight: 432.38
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 5,7-dihydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one
• InChI: InChI=1S/C21H20O10/c22-6-13-17(27)18(28)19(29)21(31-13)15-12(25)5-11(24)14-16(26)10(7-30-20(14)15)8-1-3-9(23)4-2-8/h1-5,7,13,17-19,21-25,27-29H,6H2/t13-,17-,18+,19-,21+/m1/s1
• InChIKey: HIWJJOYYZFELEZ-FFYOZGDPSA-N
• SMILES: C1=CC(=CC=C1C2=COC3=C(C2=O)C(=CC(=C3C4C(C(C(C(O4)CO)O)O)O)O)O)O

Genistein 8-C-glucoside (Cat No.:I018217) is a naturally occurring glucoside found in the flower of Lupinus luteus L. This compound has been shown to induce mitochondrial membrane depolarization, a critical event in the intrinsic apoptotic pathway. By disrupting the integrity of the mitochondrial membrane, G8CG triggers apoptosis, a programmed cell death process. These findings suggest the potential of G8CG as a natural compound with apoptotic-inducing properties, which could have implications in various fields, including cancer research and therapeutics.

Reference

[1]. Antosiak A, et al. Cytotoxic activity of genistein-8-C-glucoside form Lupinus luteus L. and genistein against human SK-OV-3 ovarian carcinoma cell line. Med Chem Res. 2017;26(1):64-73.