For research use only. Not for therapeutic Use.
Genistein (CAT: I003579) is a naturally occurring isoflavone compound found in various plants, particularly in soybeans. It possesses a range of pharmacologic activities and has been extensively studied for its potential health benefits. Genistein acts as a phytoestrogen, meaning it can bind to estrogen receptors and exert estrogen-like effects in the body. It also has antioxidant, anti-inflammatory, and anticancer properties. Genistein has shown potential in the prevention and management of several health conditions, including cardiovascular disease, osteoporosis, and certain types of cancer, such as breast and prostate cancer. Additionally, it has been investigated for its role in improving menopausal symptoms and bone health. Genistein represents a promising natural compound with diverse potential applications in health and medicine.
| Catalog Number | I003579 |
| CAS Number | 446-72-0 |
| Synonyms | 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one |
| Molecular Formula | C₁₅H₁₀O₅ |
| Purity | ≥95% |
| Target | Topoisomerase |
| Solubility | DMSO: ≥ 33 mg/mL |
| Storage | 3 years -20C powder |
| IC50 | 37.5 uM( Topo II) [3] |
| InChI | InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H |
| InChIKey | TZBJGXHYKVUXJN-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O |
| Reference | </br>1:Genistein up-regulates miR-20a to disrupt spermatogenesis via targeting Limk1. Gu H, Wu W, Yuan B, Tang Q, Guo D, Chen Y, Xia Y, Hu L, Chen D, Sha J, Wang X.Oncotarget. 2017 May 5. doi: 10.18632/oncotarget.17637. [Epub ahead of print] PMID: 28521304 Free Article</br>2:The influence of genistein on free radicals in normal dermal fibroblasts and keloid fibroblasts examined by EPR spectroscopy. Jurzak M, Ramos P, Pilawa B.Med Chem Res. 2017;26(6):1297-1305. doi: 10.1007/s00044-017-1848-3. Epub 2017 Mar 16. PMID: 28515622 </br>3:Genistein has beneficial effects on hepatic steatosis in high fat-high sucrose diet-treated rats. Liu H, Zhong H, Yin Y, Jiang Z.Biomed Pharmacother. 2017 May 13;91:964-969. doi: 10.1016/j.biopha.2017.04.130. [Epub ahead of print] PMID: 28514835 </br>4:Anti-inflammatory, anti-osteoclastic, and antioxidant activities of genistein protect against alveolar bone loss and periodontal tissue degradation in a mouse model of periodontitis. Bhattarai G, Poudel SB, Kook SH, Lee JC.J Biomed Mater Res A. 2017 May 16. doi: 10.1002/jbm.a.36109. [Epub ahead of print] PMID: 28509410 </br>5:Collagen concentration on the facial skin of postmenopausal women after topical treatment with estradiol and genistein: a randomized double-blind controlled trial. Silva LA, Ferraz Carbonel AA, de Moraes ARB, Simões RS, Sasso GRDS, Goes L, Nunes W, Simões MJ, Patriarca MT.Gynecol Endocrinol. 2017 May 16:1-4. doi: 10.1080/09513590.2017.1320708. [Epub ahead of print] PMID: 28508697 </br>6:DNA Methylation Targets Influenced by Bisphenol A and/or Genistein Are Associated with Survival Outcomes in Breast Cancer Patients. Jadhav RR, Santucci-Pereira J, Wang YV, Liu J, Nguyen TD, Wang J, Jenkins S, Russo J, Huang TH, Jin VX, Lamartiniere CA.Genes (Basel). 2017 May 15;8(5). pii: E144. doi: 10.3390/genes8050144. PMID: 28505145 Free Article</br>7:Genistein crosses the bioartificial oviduct and alters secretion composition. Simintiras CA, Sturmey RG.Reprod Toxicol. 2017 Apr 28;71:63-70. doi: 10.1016/j.reprotox.2017.04.010. [Epub ahead of print] PMID: 28461242 </br>8:Genistein modulation of seizure: involvement of estrogen and serotonin receptors. Amiri Gheshlaghi S, Mohammad Jafari R, Algazo M, Rahimi N, Alshaib H, Dehpour AR.J Nat Med. 2017 Apr 24. doi: 10.1007/s11418-017-1088-3. [Epub ahead of print] PMID: 28439683 </br>9:Genistein Ameliorates Ischemia/Reperfusion-Induced Renal Injury in a SIRT1-Dependent Manner. Li WF, Yang K, Zhu P, Zhao HQ, Song YH, Liu KC, Huang WF.Nutrients. 2017 Apr 20;9(4). pii: E403. doi: 10.3390/nu9040403. PMID: 28425936 Free PMC Article</br>10:Genistein inhibits the growth and regulates the migration and invasion abilities of melanoma cells via the FAK/paxillin and MAPK pathways. Cui S, Wang J, Wu Q, Qian J, Yang C, Bo P.Oncotarget. 2017 Mar 28;8(13):21674-21691. doi: 10.18632/oncotarget.15535. PMID: 28423510 Free PMC Article |
