For research use only. Not for therapeutic Use.
Gentamicin C1 sulfate is one of several components of the gentamicin C complex. Gentamicin C1 can comprise 25-50% gentamicin depending on the manufacturer or manufacturing process. The gentamicin C complex comprises approximately 80% gentamicin and exhibits the most potent antimicrobial activity. The higher antimicrobial activity of the group C gentamicins is thought to arise from the lack of hydroxy groups on the 3’ and 4’ positions of the purpurosamine (2-amino-hexose) fragments. Gentamicin C1 differs from gentamicin C1a by a methyl group in the 6’ position of the purpurosamine (2-amino-hexose) ring. Gentamicin C1 sulfate, is ≥95.0% gentamicin C1.</br>Aminoglycosides target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.
| Catalog Number | R012818 |
| CAS Number | 25876-10-2 |
| Synonyms | O-2-Amino-2,3,4,6,7-pentadeoxy-6-(methylamino)-α-D-ribo-heptopyranosyl-(14)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(16)]-2-deoxy-D-streptamine Pentaacetate Salt; |
| Molecular Formula | C21H43N5O7 xH2SO4 (lot specific) |
| Purity | ≥95% |
| Storage | 4°C |
| Reference | <p>Davis, Bernard D. /Mechanism of Bactericidal Action of Aminoglycosides./<em>Microbiological Reviews</em> 51.3 (1987): 341-50.</p><p>Sarna, Katarzyna, and Agata Blazewicz. /Determination of Gentamicin Sulphate Composition and Related Substances in Pharmaceutical Preparations by LC with Charged Aerosol Detection./ <em>PubMed</em> (2010)</p><p>Vydrin, A. F. /Component Composition of Gentamicin Sulfate Preparations./ Pharmaceutical Chemistry Journal 37.8 (2003): 448-49. Web. 15 Oct. 2013.</p>Weinstein, Marvin J. /Biological Activity of the Antibiotic Components of the Gentamicin Complex./ Journal of Bacteriology 94.3 (1967): 789-90. Web. 15 Oct. 2013.</span></p> |
