GENZ-644282 TFA salt

• CAT Number: I006950
• Molecular Formula: C24H22F3N3O7
• Molecular Weight: 521.45
• Purity: ≥95%
• Synonyms: GENZ-644282; GENZ644282; GENZ 644282; SAR402674; SAR 402674; SAR-402674.;2,3-dimethoxy-12-(2-(methylamino)ethyl)-[1,3]dioxolo[4/’,5/’:4,5]benzo[1,2-h]benzo[c][1,6]naphthyridin-13(12H)-one trifluoroacetic acid
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term or -20 °C for long term
• IUPAC Name: 16,17-dimethoxy-21-[2-(methylamino)ethyl]-5,7-dioxa-11,21-diazapentacyclo[11.8.0.02,10.04,8.014,19]henicosa-1(13),2,4(8),9,11,14,16,18-octaen-20-one;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C22H21N3O5.C2HF3O2/c1-23-4-5-25-21-14-8-19-20(30-11-29-19)9-16(14)24-10-15(21)12-6-17(27-2)18(28-3)7-13(12)22(25)26;3-2(4,5)1(6)7/h6-10,23H,4-5,11H2,1-3H3;(H,6,7)
• InChIKey: QMZQFWGNILZXIV-UHFFFAOYSA-N
• SMILES: CNCCN1C2=C(C=NC3=CC4=C(C=C32)OCO4)C5=CC(=C(C=C5C1=O)OC)OC.C(=O)(C(F)(F)F)O

GENZ-644282 TFA salt（Cat No.:I006950）is an investigational small molecule developed by Genzyme, designed to target and inhibit the activity of the 5-lipoxygenase activating protein (FLAP), a key regulator of leukotriene biosynthesis. Leukotrienes are inflammatory mediators involved in conditions such as asthma, allergic rhinitis, and inflammatory bowel disease. By inhibiting FLAP, GENZ-644282 reduces the production of leukotrienes, potentially providing therapeutic benefits for inflammatory and autoimmune disorders. The TFA (trifluoroacetic acid) salt form enhances the compound’s solubility and stability, and it is currently being evaluated in clinical trials for its safety and efficacy.