For research use only. Not for therapeutic Use.
Genz-644282, also known as SAR402674, is a non-camptothecin inhibitor of topoisomerase I with potential antineoplastic activity. Topoisomerase I inhibitor Genz-644282 binds to and inhibits the enzyme topoisomerase I, which may result in the inhibition of repair of single-strand DNA breaks, DNA replication, and tumor cell growth in susceptible tumor cell populations.
| Catalog Number | I006950 |
| Synonyms | GENZ-644282; GENZ644282; GENZ 644282; SAR402674; SAR 402674; SAR-402674.;2,3-dimethoxy-12-(2-(methylamino)ethyl)-[1,3]dioxolo[4/’,5/’:4,5]benzo[1,2-h]benzo[c][1,6]naphthyridin-13(12H)-one trifluoroacetic acid |
| Molecular Formula | C24H22F3N3O7 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| InChI | InChI=1S/C22H21N3O5.C2HF3O2/c1-23-4-5-25-21-14-8-19-20(30-11-29-19)9-16(14)24-10-15(21)12-6-17(27-2)18(28-3)7-13(12)22(25)26;3-2(4,5)1(6)7/h6-10,23H,4-5,11H2,1-3H3;(H,6,7) |
| InChIKey | QMZQFWGNILZXIV-UHFFFAOYSA-N |
| SMILES | O=C1N(CCNC)C2=C(C=NC3=CC(OCO4)=C4C=C32)C5=CC(OC)=C(OC)C=C15.O=C(O)C(F)(F)F |
