For research use only. Not for therapeutic Use.
GET73 is a γ-hydroxybutyric acid (GHB) analog, a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties. GET73 significantly affects glutamate transmission in the hippocampus[1][2][3].<br>GET73 (1 µM, 10 µM; 1 hour) 1 hour before and during chronic ethanol exposure prevents ethanol-induced a reduction of cell viability, an alteration of cytoskeleton, a decrease in extracellular glutamate levels and an increase of reactive oxygen species production[1].<br>GET73 (5–50 mg/kg; i.g.) exerts an anxiolytic effect in Sprague-Dawley rats exposed to the elevated plus maze (EPM) test[3].
| Catalog Number | I015434 |
| CAS Number | 202402-01-5 |
| Molecular Formula | C₁₃H₁₆F₃NO₂ |
| Purity | ≥95% |
| Reference | [1]. Tomasini MC, et al. GET73 Prevents Ethanol-Induced Neurotoxicity in Primary Cultures of Rat Hippocampal Neurons. Alcohol Alcohol. 2016 Mar;51(2):128-35.<br>[2]. Ferraro L, et al. GET73 modulates rat hippocampal glutamate transmission: evidence for a functional interaction with mGluR5. Pharmacol Rep. 2011;63(6):1359-71.<br>[3]. Loche A, et al. Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73. Front Psychiatry. 2012 Feb 14;3:8. |
