GGFG-Eribulin

• CAT Number: I040677
• CAS Number: 2841688-66-0
• Molecular Formula: C55H77N5O15
• Molecular Weight: 1048.22
• Purity: ≥95%
• Synonyms: (2S)-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]-N-[2-[[(2S)-2-hydroxy-3-[(1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,33R,35R,36S)-21-methoxy-14-methyl-8,15-dimethylidene-24-oxo-2,19,30,34,37,39,40,41-octaoxanonacyclo[24.9.2.13,32.13,33.16,9.112,16.018,22.029,36.031,35]hentetracontan-20-yl]propyl]amino]-2-oxoethyl]-3-phenylpropanamide
• InChI: InChI=1S/C55H77N5O15/c1-28-16-34-10-12-39-29(2)17-36(68-39)14-15-55-23-44-50(74-55)51-52(73-44)53(75-55)49-40(72-51)13-11-35(70-49)19-32(61)20-37-42(22-41(69-34)30(28)3)71-43(48(37)67-4)21-33(62)25-57-46(64)26-59-54(66)38(18-31-8-6-5-7-9-31)60-47(65)27-58-45(63)24-56/h5-9,28,33-44,48-53,62H,2-3,10-27,56H2,1,4H3,(H,57,64)(H,58,63)(H,59,66)(H,60,65)/t28-,33+,34+,35-,36+,37+,38+,39+,40+,41-,42+,43-,44-,48-,49+,50+,51+,52-,53+,55+/m1/s1
• InChIKey: BFAHLLXWIZBBST-KOXGGNCWSA-N
• SMILES: CC1CC2CCC3C(=C)CC(O3)CCC45CC6C(O4)C7C(O6)C(O5)C8C(O7)CCC(O8)CC(=O)CC9C(CC(C1=C)O2)OC(C9OC)CC(CNC(=O)CNC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)CN)O

GGFG-Eribulin(CAT: I040677) is a tumor-targeted chemotherapeutic conjugate that combines Eribulin, a microtubule inhibitor, with a cleavable GGFG (Gly-Gly-Phe-Gly) peptide linker. The GGFG linker is designed for enzymatic cleavage by lysosomal proteases, enabling selective drug release within cancer cells. Eribulin disrupts microtubule dynamics, causing mitotic arrest and apoptosis in rapidly dividing tumor cells. In its conjugated form, GGFG-Eribulin is often used in antibody-drug conjugates (ADCs) to improve delivery specificity and reduce systemic toxicity. This compound is a valuable tool in oncology research and therapeutic development, offering a promising approach for enhancing the efficacy of targeted cancer treatments.