For research use only, not for therapeutic use.
GGTI-2418（Cat No.:I019142）is a potent inhibitor of geranylgeranyltransferase I (GGTase I), an enzyme involved in the post-translational modification of proteins. By blocking the geranylgeranylation of small GTPases such as Rho and Ras, GGTI-2418 plays a critical role in inhibiting their activity, which is essential for cancer cell proliferation and survival. This compound has been extensively studied for its potential in cancer research, particularly in targeting signal transduction pathways associated with tumor growth and metastasis. GGTI-2418 offers valuable insights into therapeutic strategies targeting prenylation.
| Catalog Number | I019142 |
| CAS Number | 501010-06-6 |
| Molecular Formula | C₂₃H₃₁N₅O₄ |
| Purity | ≥95% |
| IUPAC Name | (2S)-2-[[(2S)-2-benzyl-4-[(5-methyl-1H-imidazol-4-yl)methyl]-3-oxopiperazine-1-carbonyl]amino]-4-methylpentanoic acid |
| InChI | InChI=1S/C23H31N5O4/c1-15(2)11-18(22(30)31)26-23(32)28-10-9-27(13-19-16(3)24-14-25-19)21(29)20(28)12-17-7-5-4-6-8-17/h4-8,14-15,18,20H,9-13H2,1-3H3,(H,24,25)(H,26,32)(H,30,31)/t18-,20-/m0/s1 |
| InChIKey | COLCNDRDBCLVOC-ICSRJNTNSA-N |
| SMILES | CC1=C(N=CN1)CN2CCN([C@H](C2=O)CC3=CC=CC=C3)C(=O)N[C@@H](CC(C)C)C(=O)O |
| Reference | [1]. Kazi A, et al. Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy. Mol Cell Biol. 2009 Apr;29(8):2254-63.<br>[2]. Kuchay S, et al. PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth. Nature. 2017 Jun 22;546(7659):554-558. |
