GGTI 298 (Trifluoroacetate Salt)

• CAT Number: R061589
• CAS Number: 1217457-86-7
• Molecular Formula: C29H34F3N3O5S
• Molecular Weight: 593.66
• Purity: ≥95%
• Synonyms: methyl(4-(((R)-2-amino-3-mercaptopropyl)amino)-2-(naphthalen-1-yl)benzoyl)leucinate 2,2,2-trifluoroacetate
• Storage: -20°C
• IUPAC Name: methyl (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-naphthalen-1-ylbenzoyl]amino]-4-methylpentanoate;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C27H33N3O3S.C2HF3O2/c1-17(2)13-25(27(32)33-3)30-26(31)23-12-11-20(29-15-19(28)16-34)14-24(23)22-10-6-8-18-7-4-5-9-21(18)22;3-2(4,5)1(6)7/h4-12,14,17,19,25,29,34H,13,15-16,28H2,1-3H3,(H,30,31);(H,6,7)/t19-,25+;/m1./s1
• InChIKey: WALKWJPZELDSKT-UFABNHQSSA-N
• SMILES: CC(C)C[C@@H](C(=O)OC)NC(=O)C1=C(C=C(C=C1)NC[C@H](CS)N)C2=CC=CC3=CC=CC=C32.C(=O)(C(F)(F)F)O

GGTI 298 (Trifluoroacetate Salt)（Cat No.:R061589）is a selective inhibitor of geranylgeranyltransferase I (GGTase I), an enzyme responsible for the post-translational modification of proteins like small GTPases. By inhibiting GGTase I, GGTI 298 prevents the attachment of geranylgeranyl groups to proteins, disrupting their localization and function in cell signaling pathways. This makes it a valuable tool in cancer research, where it is used to study the role of GTPases in tumor growth and progression. GGTI 298 is also being investigated for its potential therapeutic applications in oncology and other diseases driven by abnormal protein prenylation.