GGTI2417

• CAT Number: I028022
• CAS Number: 501010-05-5
• Molecular Formula: C24H33N5O4
• Molecular Weight: 455.56
• Purity: 98%
• Synonyms: GGTI2417; GGTI-2417; GGTI2417.
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: methyl (2S)-2-[[(2S)-2-benzyl-4-[(5-methyl-1H-imidazol-4-yl)methyl]-3-oxopiperazine-1-carbonyl]amino]-4-methylpentanoate
• InChI: InChI=1S/C24H33N5O4/c1-16(2)12-19(23(31)33-4)27-24(32)29-11-10-28(14-20-17(3)25-15-26-20)22(30)21(29)13-18-8-6-5-7-9-18/h5-9,15-16,19,21H,10-14H2,1-4H3,(H,25,26)(H,27,32)/t19-,21-/m0/s1
• InChIKey: DWKYALWDWAYMTB-FPOVZHCZSA-N
• SMILES: CC1=C(N=CN1)CN2CCN([C@H](C2=O)CC3=CC=CC=C3)C(=O)N[C@@H](CC(C)C)C(=O)OC

GGTI-2417（Cat No.:I028022）is a small molecule inhibitor targeting geranylgeranyltransferase I (GGTase-I), an enzyme involved in the post-translational modification of proteins, particularly the geranylgeranylation of small GTPases like Rho, Rac, and Cdc42. These GTPases play a key role in cell signaling, growth, and survival. By inhibiting GGTase-I, GGTI-2417 disrupts the activation of these GTPases, which can help reduce cancer cell proliferation and metastasis. It has been investigated for its potential as an anti-cancer therapy, particularly in solid tumors, and is undergoing clinical trials to assess its safety and efficacy in oncology.