GGTI298

• CAT Number: I002352
• CAS Number: 180977-44-0
• Molecular Formula: C27H33N3O3S
• Molecular Weight: 479.63
• Purity: ≥95%
• Synonyms: GGTI 298; GGTI-298.
• Target: Apoptosis
• Solubility: Soluble to 25 mM in DMSO
• Storage: Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -42℃ for long term (months to years).
• IC50: 3 μM against processing of Rap 1A
• IUPAC Name: methyl (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-naphthalen-1-ylbenzoyl]amino]-4-methylpentanoate
• InChI: InChI=1S/C27H33N3O3S/c1-17(2)13-25(27(32)33-3)30-26(31)23-12-11-20(29-15-19(28)16-34)14-24(23)22-10-6-8-18-7-4-5-9-21(18)22/h4-12,14,17,19,25,29,34H,13,15-16,28H2,1-3H3,(H,30,31)/t19-,25+/m1/s1
• InChIKey: XVWPFYDMUFBHBF-CLOONOSVSA-N
• SMILES: CC(C)C[C@@H](C(=O)OC)NC(=O)C1=C(C=C(C=C1)NC[C@H](CS)N)C2=CC=CC3=CC=CC=C32

GGTI 298（Cat No.:I002352）is a selective inhibitor of geranylgeranyltransferase I (GGTase I), an enzyme that modifies proteins such as small GTPases, including Rho, Rac, and Rab. These proteins play vital roles in cell signaling, cytoskeletal organization, and cell proliferation. By inhibiting GGTase I, GGTI 298 prevents the proper membrane localization and function of these proteins, disrupting processes involved in cancer progression and metastasis. GGTI 298 is widely used in research to explore the role of protein prenylation in cancer and to investigate potential therapeutic strategies targeting protein modification pathways.

Reference

[1]. Sheikh IA, et al. The Epac1 signaling pathway regulates Cl- secretion via modulation of apical KCNN4c channels in diarrhea. J Biol Chem. 2013 Jul 12;288(28):20404-15. 


[2]. Chen S, et al. Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis. Mol Cancer. 2010 Jan 29;9:23.