GHK-Cu acetate

• CAT Number: I028027
• CAS Number: 300801-03-0
• Molecular Formula: C16H26CuN6O6
• Molecular Weight: 461.97
• Purity: 95%
• Synonyms: GHK-Cu acetate, Gly-His-Lys-Cu(II)
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: [glycyl-κN-L-histidyl-κN,κN3-L-lysinato(2-)]-copper, monoacetate
• InChI: InChI=1S/C14H24N6O4.C2H4O2.Cu/c15-4-2-1-3-10(14(23)24)20-13(22)11(19-12(21)6-16)5-9-7-17-8-18-9;1-2(3)4;/h7-8,10-11H,1-6,15-16H2,(H4,17,18,19,20,21,22,23,24);1H3,(H,3,4);/q;;+2/p-2/t10-,11-;;/m0../s1
• InChIKey: NOIHSRSQDMJJFH-ULEGLUPFSA-L
• SMILES: CC(O)=O.O=C([C@H]1[N-](C2=O)[Cu+2]([NH2]C2)[N]3=CNC=C3C1)N[C@H](C([O-])=O)CCCCN

GHK-Cu acetate(CAT: I028027), also known as Copper Peptide GHK-Cu, is a peptide complex composed of the tripeptide GHK (glycyl-l-histidyl-l-lysine) and copper (Cu). GHK-Cu is a naturally occurring peptide in the human body and has been found to have various biological activities, including wound healing, tissue regeneration, and anti-aging effects. The addition of copper to GHK enhances its activity and stability. GHK-Cu acetate is commonly used in skincare products for its potential benefits in promoting collagen production, improving skin elasticity, and reducing the appearance of wrinkles and fine lines.

Reference

1. Siméon, A., Emonard, H., Hornebeck, W., et al. The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures. Life Sci. 67(18), 2257-2265 (2000).
2. Maquart, F.-X., Pickart, L., Laurent, M., et al. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Lett. 238(2), 343-346 (1988).
3. Park, J.-R., Lee, H., Kim, S.-I., et al. The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice. Oncotarget 7(36), 58405-58417 (2016).
4. Pollard, J.D., Quan, S., Kang, T., et al. Effects of copper tripeptide on the growth and expression of growth factors by normal and irradiated fibroblasts. Arch. Facial Plast. Surg. 7(1), 27-31 (2005).
5. Siméon, A., Wegrowski, Y., Bontemps, Y., et al. Expression of glycosaminoglycans and small proteoglycans in wounds: Modulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. J. Invest. Dermatol. 115(6), 962-968 (2000).