Gimeracil

• CAT Number: I000224
• CAS Number: 103766-25-2
• Molecular Formula: C5H4ClNO2
• Molecular Weight: 145.54
• Purity: ≥95%
• Synonyms: 5-chloro-4-hydroxy-1H-pyridin-2-one
• Target: Dehydrogenase
• Solubility: DMSO 29 mg/ml
• Storage: 3 years -20C powder
• InChI: InChI=1S/C5H4ClNO2/c6-3-2-7-5(9)1-4(3)8/h1-2H,(H2,7,8,9)
• InChIKey: ZPLQIPFOCGIIHV-UHFFFAOYSA-N
• SMILES: C1=C(C(=CNC1=O)Cl)O

Gimeracil (Gimestat)(CAT: I000224) is a potent inhibitor of dihydropyrimidine dehydrogenase (DPYD), the enzyme responsible for the degradation of pyrimidines, including the chemotherapeutic agent 5-fluorouracil (5-FU). By inhibiting DPYD, Gimeracil increases the systemic availability and efficacy of 5-FU, enhancing its anticancer effects. Additionally, Gimeracil has been shown to inhibit homologous recombination, a critical DNA repair mechanism, which further sensitizes cancer cells to DNA-damaging therapies. This dual mechanism makes it a valuable compound in oncology research, particularly for exploring combination therapies aimed at improving the efficacy of pyrimidine-based treatments and targeting DNA repair pathways in cancer cells.