For research use only. Not for therapeutic Use.
Ginsenoside Rg5 (Cat No.:I002412 ) is a bioactive saponin compound found in Panax ginseng. It has demonstrated a range of pharmacological properties, including anti-inflammatory, neuroprotective, and anticancer effects. Ginsenoside Rg5 is believed to exert its beneficial effects by modulating cellular pathways involved in oxidative stress, inflammation, and apoptosis. Research suggests it may improve cognitive function, protect against neurodegenerative diseases, and inhibit tumor growth. As a result, Ginsenoside Rg5 is being explored for its therapeutic potential in various diseases, particularly neurodegenerative disorders and cancer.
| CAS Number | 186763-78-0 |
| Molecular Formula | C42H70O12 |
| Purity | ≥95% |
| Target | NF-κB |
| Solubility | 10 mM in DMSO |
| Storage | -20℃ |
| IUPAC Name | (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-4,4,8,10,14-pentamethyl-17-[(2E)-6-methylhepta-2,5-dien-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol |
| InChI | 1S/C42H70O12/c1-21(2)10-9-11-22(3)23-12-16-42(8)30(23)24(45)18-28-40(6)15-14-29(39(4,5)27(40)13-17-41(28,42)7)53-38-36(34(49)32(47)26(20-44)52-38)54-37-35(50)33(48)31(46)25(19-43)51-37/h10-11,23-38,43-50H,9,12-20H2,1-8H3/b22-11+/t23-,24-,25-,26-,27+,28-,29+,30+,31-,32-,33+,34+,35-,36-,37+,38+,40+,41-,42-/m1/s1 |
| InChIKey | NJUXRKMKOFXMRX-RNCAKNGISA-N |
| SMILES | CC(=CC/C=C(\C)/[C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)O)C)C |
| Reference | [1]. Kim TW, et al. Ginsenoside Rg5 ameliorates lung inflammation in mice by inhibiting the binding of LPS to toll-like receptor-4 on macrophages. Int Immunopharmacol. 2012 Jan;12(1):110-6. [2]. Chu S, et al. Ginsenoside Rg5 improves cognitive dysfunction and beta-amyloid deposition in STZ-induced memory impaired rats via attenuating neuroinflammatory responses. Int Immunopharmacol. 2014 Apr;19(2):317-26. [3]. Cho YL, et al. Specific activation of insulin-like growth factor-1 receptor by ginsenoside Rg5 promotes angiogenesis and vasorelaxation. J Biol Chem. 2015 Jan 2;290(1):467-77. [4]. Kim EJ, et al. Ginsenosides Rg5 and Rh3 protect scopolamine-induced memory deficits in mice. J Ethnopharmacol. 2013 Mar 7;146(1):294-9.
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