Givinostat free base

• CAT Number: I006964
• CAS Number: 497833-27-9
• Molecular Formula: C24H27N3O4
• Molecular Weight: 421.49
• Purity: ≥95%
• Target: HDAC inhibitor
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term or -20 °C for long term
• IUPAC Name: [6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate
• InChI: InChI=1S/C24H27N3O4/c1-3-27(4-2)15-17-5-7-21-14-18(6-8-20(21)13-17)16-31-24(29)25-22-11-9-19(10-12-22)23(28)26-30/h5-14,30H,3-4,15-16H2,1-2H3,(H,25,29)(H,26,28)
• InChIKey: YALNUENQHAQXEA-UHFFFAOYSA-N
• SMILES: O=C(OCC1=CC=C2C=C(CN(CC)CC)C=CC2=C1)NC3=CC=C(C(NO)=O)C=C3

Givinostat(CAT: I006964) is a potent histone deacetylase (HDAC) inhibitor with anti-inflammatory and anti-proliferative properties. By inhibiting HDAC enzymes, it modulates chromatin structure and gene expression, leading to the suppression of inflammatory cytokines and the arrest of abnormal cell proliferation. Givinostat Free Base is particularly significant in oncology and immunology research, where it has shown promise in treating hematological malignancies, such as polycythemia vera, and inflammatory diseases. Its ability to target HDAC-related pathways provides a valuable tool for exploring therapeutic strategies aimed at epigenetic regulation and disease modification in cancer and immune-mediated disorders.