For research use only. Not for therapeutic Use.
Givinostat hydrochloride monohydrate（Cat No.:I013160）is a potent histone deacetylase (HDAC) inhibitor with anti-inflammatory and anticancer properties. It works by inhibiting HDAC enzymes, leading to increased acetylation of histone proteins, which alters gene expression and induces cell cycle arrest, differentiation, and apoptosis in cancer cells. Givinostat is being investigated for the treatment of various cancers, including leukemia and multiple myeloma, as well as inflammatory conditions like Duchenne muscular dystrophy. Its ability to modulate epigenetic mechanisms makes it a promising therapeutic agent for targeting disease pathways involving abnormal cell proliferation and inflammation.
| Catalog Number | I013160 |
| CAS Number | 732302-99-7 |
| Molecular Formula | C₂₄H₃₀ClN₃O₅ |
| Purity | ≥95% |
| Target | HDAC |
| Solubility | DMSO：≥ 100 mg/mL |
| IUPAC Name | [6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate;hydrate;hydrochloride |
| InChI | InChI=1S/C24H27N3O4.ClH.H2O/c1-3-27(4-2)15-17-5-7-21-14-18(6-8-20(21)13-17)16-31-24(29)25-22-11-9-19(10-12-22)23(28)26-30;;/h5-14,30H,3-4,15-16H2,1-2H3,(H,25,29)(H,26,28);1H;1H2 |
| InChIKey | FKGKZBBDJSKCIS-UHFFFAOYSA-N |
| SMILES | CCN(CC)CC1=CC2=C(C=C1)C=C(C=C2)COC(=O)NC3=CC=C(C=C3)C(=O)NO.O.Cl |
| Reference | [1]. Li S, et al. Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo. J Biol Chem. 2015 Jan 23;290(4):2368-78.<br>[2]. Wang YG, et al. Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation. World J Gastroenterol. 2015 Jul 21;21(27):8326-39.<br>[3]. Leoni F, et al. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med. 2005 Jan-Dec;11(1-12):1-15. |
