For research use only. Not for therapeutic Use.
GJ-103 free acid（Cat No.:I006966）is a selective small molecule compound being studied for its potential therapeutic applications, particularly in oncology. It is known to target and inhibit specific signaling pathways involved in cancer cell growth and survival. GJ-103 free acid has shown preclinical activity against various cancer cell lines, demonstrating its ability to interfere with tumor progression. Its mechanism of action includes modulating cellular processes like apoptosis and proliferation. Ongoing research aims to assess its efficacy and safety, as well as its potential as a targeted therapy for specific types of cancer.
| Catalog Number | I006966 |
| CAS Number | 1459687-89-8 (free acid) |
| Synonyms | GJ-103 free acid; GJ103; GJ 103; GJ-103.;2-((4-(3-methoxyphenyl)-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetic acid |
| Molecular Formula | C16H14N4O3S |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term or -20 °C for long term |
| IUPAC Name | 2-[[4-(3-methoxyphenyl)-5-pyridin-2-yl-1,2,4-triazol-3-yl]sulfanyl]acetic acid |
| InChI | InChI=1S/C16H14N4O3S/c1-23-12-6-4-5-11(9-12)20-15(13-7-2-3-8-17-13)18-19-16(20)24-10-14(21)22/h2-9H,10H2,1H3,(H,21,22) |
| InChIKey | GBVQSAZHPCDBDY-UHFFFAOYSA-N |
| SMILES | COC1=CC=CC(=C1)N2C(=NN=C2SCC(=O)O)C3=CC=CC=N3 |
| Reference | </br>1:Pimelic acid, the first precursor of the Bacillus subtilis biotin synthesis pathway, exists as the free acid and is assembled by fatty acid synthesis. Manandhar M, Cronan JE.Mol Microbiol. 2017 May;104(4):595-607. doi: 10.1111/mmi.13648. Epub 2017 Mar 3. PMID: 28196402 </br>2:Pharmacokinetic and pharmacodynamic characterization of ceftiofur crystalline-free acid following subcutaneous administration in domestic goats. Waraich GS, Sidhu PK, Daundkar PS, Kaur G, Sharma SK.J Vet Pharmacol Ther. 2016 Dec 12. doi: 10.1111/jvp.12373. [Epub ahead of print] PMID: 27943295 </br>3:Vaccination mitigates the impact of PRRSv infection on the pharmacokinetics of ceftiofur crystalline-free acid in pigs. Sparks JW, Karriker LA, Day DN, Wulf LW, Zhang J, Stock ML, Bates JL, Gehring R, Coetzee JF.J Vet Pharmacol Ther. 2016 Nov 24. doi: 10.1111/jvp.12369. [Epub ahead of print] PMID: 27885695 </br>4:PHARMACOKINETICS OF CEFTIOFUR CRYSTALLINE FREE ACID, A LONG-ACTING CEPHALOSPORIN, IN AMERICAN FLAMINGOS (PHOENICOPTERUS RUBER). Kilburn JJ, Cox SK, Backues KA.J Zoo Wildl Med. 2016 Jun;47(2):457-62. doi: 10.1638/2015-0278.1. PMID: 27468016 </br>5:Dissolution Methods to Increasing Discriminatory Power of In Vitro Dissolution Testing for Ibuprofen Free Acid and Its Salts. Cristofoletti R, Dressman JB.J Pharm Sci. 2017 Jan;106(1):92-99. doi: 10.1016/j.xphs.2016.06.001. Epub 2016 Jul 7. PMID: 27397434 </br>6:Pharmacokinetic parameters for single- and multi-dose regimens for subcutaneous administration of a high-dose ceftiofur crystalline-free acid to neonatal foals. Pusterla N, Hall TL, Wetzlich SE, Monmaney G, Collier JR, Hill JA, Tell LA.J Vet Pharmacol Ther. 2017 Jan;40(1):88-91. doi: 10.1111/jvp.12327. Epub 2016 Jun 13. PMID: 27292121 </br>7:Pharmacokinetics of Ceftiofur Crystalline-Free Acid in Clinically Healthy Dogs (Canis lupus familiaris). Hooper SE, Korte SW, Giguère S, Fales WH, Davis JL, Dixon LW.J Am Assoc Lab Anim Sci. 2016 Mar;55(2):224-9. PMID: 27025816 Free PMC Article</br>8:Effects of Supplemental Liquid DL-methionine Hydroxy Analog Free Acid in Diet on Growth Performance and Gastrointestinal Functions of Piglets. Kaewtapee C, Krutthai N, Bunchasak C.Asian-Australas J Anim Sci. 2016 Aug;29(8):1166-72. doi: 10.5713/ajas.15.0579. Epub 2016 Jan 29. PMID: 26954213 Free PMC Article</br>9:Efficacy of DL-methionine hydroxy analogue-free acid in comparison to DL-methionine in growing male white Pekin ducks. Kluge H, Gessner DK, Herzog E, Eder K.Poult Sci. 2016 Mar;95(3):590-4. doi: 10.3382/ps/pev355. Epub 2015 Dec 25. PMID: 26706358 </br>10:Pharmacokinetics of a single intramuscular injection of ceftiofur crystalline-free acid in red-tailed hawks (Buteo jamaicensis). Sadar MJ, Hawkins MG, Byrne BA, Cartoceti AN, Keel K, Drazenovich TL, Tell LA.Am J Vet Res. 2015 Dec;76(12):1077-84. doi: 10.2460/ajvr.76.12.1077. PMID: 26618733 |
